Yasumon Thinka. Comparison of modified formalism output and TRS-398 absorbed dose to water in electron beams reference dosimetry in multiple radiotherapy centers. Master's Degree(Medical Physics). Chulalongkorn University. Office of Academic Resources. : Chulalongkorn University, 2023.
Comparison of modified formalism output and TRS-398 absorbed dose to water in electron beams reference dosimetry in multiple radiotherapy centers
Abstract:
The study aimed to investigate the feasibility and efficacy of utilizing modified calibration with cylindrical chambers for reference dosimetry in electron beam radiotherapy, challenging the recommendation of using plane-parallel chambers in low-energy electron beams by IAEA's TRS-398 and AAPM's TG-51 standards. Data collection involved six radiotherapy centers in Bangkok using Varian linear accelerators, with chambers including the IBA FC65-G, PTW 30013 cylindrical chambers, and PPC40, Roos plane-parallel chambers. Results of dose comparison between modified and TRS-398 protocols fell within ±2%. For low-energy electron beams, percent dose discrepancies ranged from -1.57% to 0.91%, and from -0.37% to 0.91% for high-energy. The wider range in low-energy discrepancies may arise from chamber-to-chamber variations, setup errors, interpolating of values, contributing to higher uncertainty in the cross-calibration process. The mean difference of dose between the two protocols was 0.0002 ± 0.0055 cGy/MU, indicating no significant bias on average. Results within the 95% confidence interval affirmed the methods' similarity, ensuring reliable measurements and confirming a viable alternative for reference dosimetry of electron beams. However, limitations included the limited variation in the types of cylindrical chamber models tested, and further investigation into uncertainties is warranted to optimize accuracy and reliability of dose measurements.