Abstract:
This study was aimed to test the inhibitory effect of Candida albicans activity of 4 selected
medicinal plant species base on Thai traditional medicine text book: Curcuma zedoaria Roscoe Rhizome,
Uncaria gambir (Hunter) Roxb.Stem bark, Gardenia turgida Roxb. seeds, and Hydnocarpus anthelminthicus
Pierre ex Laness seeds. The bioactive compounds were extracted by Soxhlet extraction with petroleum
ether, dichlolomethane, acetone and methanol, respectively. The acetone extract of U. gambir Stem bark
showed the highest yield at 23.9 percent, and the petroleum ether extract of U. gambir Stem bark showed the
lowest yield at 0.10 percent. Crude extract was tested for their inhibitory effect of C. albican activity by the agar
disc diffusion assay and microbroth dilution method. The methanolic extract of C. zedoaria Rhizome
showed the lowest inhibitory effect of C. albican activity, zone of inhibition with value of 1.0±0.00 mm.
and the petroleum ether extract of and H. anthelminthicus Pierre ex Laness seeds showed the highest
inhibitory effectof C. albican activity, zone of inhibition with value of 13.3±0.49 mm. The dicholomethane
extract of C. zedoaria Roscoe Rhizome showed minimum inhibitory concentration (MIC) with value of
3.125 mg/mL. The dicholomethane extract of C. zedoaria Roscoe Rhizome showed minimum fungicidal
concentration (MFC) with value of 6.25 mg/ mL.