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Chayanit Soontara. Adjuvant effects of a CC chemokine for enhancing the efficacy of an inactivated streptococcus agalactiae vaccine in Nile Tilapia (Oreochromis niloticus). Master's Degree(Aquaculture). Kasetsart University. Office of the University Library. : Kasetsart University, 2023.
Adjuvant effects of a CC chemokine for enhancing the efficacy of an inactivated streptococcus agalactiae vaccine in Nile Tilapia (Oreochromis niloticus)
Name: Chayanit Soontara
Classification :.LCCS: SH179.N54
LCSH:
Streptococcus agalactiae
-- Vaccination
LCSH:
Chemokines
-- Therapeutic use
Abstract:
In the current study, the effects of CC chemokine (On-CC1) as a vaccine adjuvant for enhancing the efficacy of inactivated Streptococcus agalactiae vaccine (WC) in inducing immune responses against Streptococcus agalactiae in Nile tilapia was investigated through ELISA assays, immune-related gene expression analysis, and challenge tests. The significantly heightened IgM-specific levels to S. agalactiae were firstly detected in fish vaccinated with the WC+CC group at 8 days-post vaccination (dpv) compared to those vaccinated with WC alone or control groups. The WC vaccine group exhibited increased IgM-specific levels at 15 dpv comparable to the WC+CC group, with sustained higher levels observed in the latter at 29 dpv. Survival fish from vaccinated groups showed significantly higher IgM-specific levels compared to controls after challenge with S. agalactiae. Immune-related gene expression analysis revealed upregulation of IgM, TNF-α, IFN-γ, IL-1b, IL8(1) (CXC1), IL8(2) (CXC2), On-CC1, and On-CC2 genes in vaccinated groups compared to controls, with notable differences between WC and WC+CC groups at various dpvs. Challenge tests fish with a harmful strain of S. agalactiae, the survival rates were notably higher in the WC and WC+CC vaccinated groups, with rates of 73.33% and 54.67%, respectively, compared to the control groups rate of 24.00%. Furthermore, a significant survival advantage was observed in the WC+CC vaccine group compared to the WC group. Overall, these findings underscore the effectiveness of both WC and WC+CC vaccines in inducing immune responses and enhancing survival rates against S. agalactiae in Nile tilapia, with the WC+CC vaccine showing superior efficacy in certain aspects
Kasetsart University. Office of the University Library
Address:
Bangkok
Email:
tdckulib@ku.ac.th
Name: Prapansak Srisapoome
Role:
Thesis Advisor
Name: Anurak Uchuwittayakul
Role:
Thesis Co-Advisor
Created:
2023
Modified:
2026-06-16
Issued:
2026-06-16
วิทยานิพนธ์/Thesis
application/pdf
URL: https://kasetsart.idm.oclc.org/login?url=https://www.lib.ku.ac.th/KUthesis/2566/chayanit-soon-all.pdf
CallNumber:
SH179.N54.C43
eng
DegreeName: Master of Science
Level: Master's Degree
Descipline: Aquaculture
Grantor: Kasetsart University
©copyrights Kasetsart University
RightsAccess:
ใช้เวลา
0.043029 วินาที
Chayanit Soontara
| Title | Contributor | Type |
|---|---|---|
| Adjuvant effects of a CC chemokine for enhancing the efficacy of an inactivated streptococcus agalactiae vaccine in Nile Tilapia (Oreochromis niloticus)
มหาวิทยาลัยเกษตรศาสตร์ Chayanit Soontara | Prapansak Srisapoome Anurak Uchuwittayakul | วิทยานิพนธ์/Thesis |
Prapansak Srisapoome
Anurak Uchuwittayakul
| Title | Creator | Type and Date Create |
|---|---|---|
| Adjuvant effects of a CC chemokine for enhancing the efficacy of an inactivated streptococcus agalactiae vaccine in Nile Tilapia (Oreochromis niloticus)
มหาวิทยาลัยเกษตรศาสตร์ Prapansak Srisapoome;Anurak Uchuwittayakul | Chayanit Soontara | วิทยานิพนธ์/Thesis |