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Kongla Sopachai. Single Nucleotide Polymorphisms Association Studies of Presenilin 1 Gene in Thai Alzheimer's Disease Patients. Master's degree(Medical Sciences). NARESUAN UNIVERSITY. NARESUAN UNIVERSITY LIBRARY. : Naresuan University, 2012.
Single Nucleotide Polymorphisms Association Studies of Presenilin 1 Gene in Thai Alzheimer's Disease Patients
Name: Kongla Sopachai
keyword:
Single nucleotide polymorphisms
Abstract:
Single nucleotide polymorphisms (SNPs) in amyloid precursor protein (APP) and presenilin (PSEN) gene are known to cause early onset Alzheimer's disease (EOAD) but different in ethnic groups. The purposes of this research were to study SNPs association studies of presenilin 1 gene (PSEN1) in Thai Alzheimer's disease patients. The studies were following with as case-control study using HapMap database to identify the SNPs. The identified tagSNPs in the PSEN1 of Han, Chinese from Beijing, China as a model for Thailand are rs3025780 (Intron 3), rs214273 (Intron 3), rs362340 (Intron 4), rs165932 (Intron 8), rs165933 (Intron 8) and rs10146743 (Intron 9). The 15 Alzheimer's disease patients and 15 controls were recruited using activities of daily living, behaviors and cognitive function evaluation from Memorial Clinic, Chiangmai Neurological Hospital, Chiangmai, Thailand. ÿÿÿÿÿÿÿÿThis study reported that 13.33% showed as GA heterozygous alleles in rs165933 for both Alzheimer's disease patients and controls. In Alzheimer's disease patients, the GA heterozygous was about 20%, when only 6.66% showed in the controls. Association studies using odd ratio (95% CI) in the rs165933 in PSEN1 showed GG, GA and AA alleles at 0.33 (95% CI=0.0275-4.0359), 4.20 (95% CI=0.3320-53.1253), and 0.24 (95% CI=0.0188-3.0117), respectively. Therefore, the rs165933 (Intron 8) genotypes (GG and GA alleles) could be a candidate SNPs marker of PSEN1 in Thai population. However, large sample size both Alzheimer's disease patients and controls must be verified.
NARESUAN UNIVERSITY. NARESUAN UNIVERSITY LIBRARY
Address:
PHITSANULOK
Email:
library@nu.ac.th
Name: Sukkid Yasothornsrikul
Role:
Advisor
Name: Sutisa Thanoi
Role:
Co-Advisor
Name: Suparus Wangtongkum
Role:
Co-Advisor
Created:
2012
Modified:
2569-04-29
Issued:
2026-04-29
ÇÔ·ÂÒ¹Ô¾¹¸ì/Thesis
application/pdf
eng
DegreeName: Master of Science
Level: Master's degree
Descipline: Medical Sciences
Grantor: Naresuan University
©copyrights Naresuan University
RightsAccess:
ãªéàÇÅÒ
0.047253 ÇÔ¹Ò·Õ
Kongla Sopachai
| Title | Contributor | Type |
|---|---|---|
| Single Nucleotide Polymorphisms Association Studies of Presenilin 1 Gene in Thai Alzheimer\'s Disease Patients
ÁËÒÇÔ·ÂÒÅѹàÃÈÇà Kongla Sopachai | Sukkid Yasothornsrikul Sutisa Thanoi Suparus Wangtongkum | ÇÔ·ÂÒ¹Ô¾¹¸ì/Thesis |
| Single Nucleotide Polymorphisms Association Studies of Presenilin 1 Gene in Thai Alzheimer\'s Disease Patients
ÁËÒÇÔ·ÂÒÅѹàÃÈÇà Kongla Sopachai | Sukkid Yasothornsrikul | ÇÔ·ÂÒ¹Ô¾¹¸ì/Thesis |
Sukkid Yasothornsrikul
Sutisa Thanoi
Suparus Wangtongkum
| Title | Creator | Type and Date Create |
|---|---|---|
| Single Nucleotide Polymorphisms Association Studies of Presenilin 1 Gene in Thai Alzheimer\'s Disease Patients
ÁËÒÇÔ·ÂÒÅѹàÃÈÇà Sukkid Yasothornsrikul;Sutisa Thanoi;Suparus Wangtongkum | Kongla Sopachai | ÇÔ·ÂÒ¹Ô¾¹¸ì/Thesis |