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Rittipun Rungruang.. Citric acid production by Aspergillus niger in stirred tank bioreactor. (). King Mongkut's University of Technology North Bangkok. Central Library. : , 2026.
Citric acid production by Aspergillus niger in stirred tank bioreactor
Name: Kanjana Detchomphoo.
Organization :
King Mongkuts University of Technology North Bangkok. Faculty of Applied Science
Name: Nicharee Wisuthiphaet.
Organization :
King Mongkuts University of Technology North Bangkok. Faculty of Applied Science
Email :
nicharee.w@sci.kmutnb.ac.th
Name: Sasithorn Kongruang.
Organization :
King Mongkuts University of Technology North Bangkok. Faculty of Applied Science
Email :
sasithorn.k@sci.kmutnb.ac.th
Name: Rittipun Rungruang.
Organization :
Suan Dusit University. Faculty of Science and Technology
keyword:
Box-Behnken design.
LCSH:
Aspergillus niger.
LCSH:
Citric acid.
LCSH:
Fermentation.
LCSH:
Bioreactors
-- Design and construction.
LCSH:
Experimental design.
Abstract:
The optimization of citric acid production by submerged fermentation using Aspergillus niger TISTR 2365 was studied on upstream and downstream processing using a modified medium. The Box-Behnken Design was used for optimization, varying carbon to nitrogen ratios (70, 85, 100 g/L), shaking speed (200, 250, 300 rpm), and CaCl2 supplementation (0.01, 0.055, 0.1 g/L) across 17 experimental runs. Batch fermentations were conducted in a 250 mL Erlenmeyer flask for 7 days at 30 °C. Results found the optimum citric acid was obtained at 27.73 g/L at a carbon to nitrogen ratio of 97.32 g/g, shaking speed of 300 rpm, and CaCl2 supplementation of 0.10 g/L. Model validation of citric acid production of 25.43 g/L was confirmed in a 5-L stirred tank bioreactor, with an 8.29 percent deviation from the predicted value. Three operational runs in a bioreactor yielded citric acid concentrations of 26.88 g/L, 21.76 g/L, and 26.88 g/L, respectively. The highest citric acid yield was achieved in the third batch, reaching 0.25 g/g glucose, while the average yield from substrate utilization was approximately 0.20 g/g glucose. The results highlight the effectiveness of fermentation conditions and the role of CaCl₂ in enhancing citric acid production. Downstream processing was performed to purify the citric acid by the precipitation method. Purified citric acid was then quantified and analyzed by HPLC and FTIR."
King Mongkut's University of Technology North Bangkok. Central Library
Address:
BANGKOK
Email:
library@kmutnb.ac.th
Created:
2026
Modified:
2569-02-17
Issued:
2026-02-17
บทความ/Article
application/pdf
BibliograpyCitation :
APPLIED SCIENCE AND ENGINEERING PROGRESS. vol. 19, no. 1 (Jan.-Mar. 2026), p. 1-16.
eng
©copyrights King Mongkut's University of Technology North Bangkok
RightsAccess:
ใช้เวลา
0.04849 วินาที
Kanjana Detchomphoo.
| Title | Contributor | Type |
|---|---|---|
| Citric acid production by Aspergillus niger in stirred tank bioreactor
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Kanjana Detchomphoo.;Nicharee Wisuthiphaet.;Sasithorn Kongruang.;Rittipun Rungruang. | บทความ/Article |
Nicharee Wisuthiphaet.
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|---|---|---|
| A review on the effect of ultrasonic-assisted curing on the quality of meat products
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Yongzheng Hu.;Suvaluk Asavasanti.;Roungdao Klinjapo.;Watanya Chaisayan.;Patchanee Yasurin.;Nicharee Wisuthiphaet.;Chen, Qiuxin. | บทความ/Article | |
| Citric acid production by Aspergillus niger in stirred tank bioreactor
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Kanjana Detchomphoo.;Nicharee Wisuthiphaet.;Sasithorn Kongruang.;Rittipun Rungruang. | บทความ/Article |
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| Citric acid production by Aspergillus niger in stirred tank bioreactor
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Kanjana Detchomphoo.;Nicharee Wisuthiphaet.;Sasithorn Kongruang.;Rittipun Rungruang. | บทความ/Article |
Rittipun Rungruang.
| Title | Contributor | Type |
|---|---|---|
| Citric acid production by Aspergillus niger in stirred tank bioreactor
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Kanjana Detchomphoo.;Nicharee Wisuthiphaet.;Sasithorn Kongruang.;Rittipun Rungruang. | บทความ/Article | |
| Enhanced broad-spectrum protection against high-energy visible light using co-doped Ag2O and ZnO-TiO2 nanocomposites
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Wittawat Ratanathavorn.;Wittawat Ratanathavorn.;Nattaporn Boohuad.;Rittipun Rungruang. | บทความ/Article |