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Natjaya Ekapakul. Chitosan-based composite hydrogel preparation and characterization. Master's Degree(Nanomaterials Science). Kasetsart University. Office of the University Library. : Kasetsart University, 2019.
Chitosan-based composite hydrogel preparation and characterization
Name: Natjaya Ekapakul
Classification :.LCCS: TP1180.P6
LCSH:
Polycaprolactone
LCSH:
Composite materials
LCSH:
Chitosan
LCSH:
Chitin
Abstract:
Star-shaped polycaprolactone (stPCL)/chitosan composite hydrogel was fabricated via simply melt/solution blending between chitosan/dicarboxylic acid solution and melted stPCL, using 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide as conjugating agents to obtain a composite hydrogel. This work, we focused on preparation and characterization of composite hydrogel. The stPCL was modified to have a carboxyl-terminated chain (stPCL-COOH). The composite hydrogel was transparent. The network structure of composite hydrogels was investigated. stPCL-OH had no chemical bond to the chitosan network but stPCL-COOH could co-crosslink with the chitosan network. The porous structure and porosity of the composite hydrogel were similar to chitosan hydrogel. However, the hydrophobicity of stPCL resulted in a lower swelling ratio compared to chitosan hydrogel. The rheological analysis of composite hydrogel exhibited a stable crosslinked network. Compressive mechanical testing of composite hydrogel showed that the optimum condition of composite hydrogel to have compressive mechanical properties comparable to chitosan hydrogel was stPCL-COOH with mole ratio to chitosan as 1:1. This might be due to the synergistic effect of the flexibility of stPCL and the co-crosslinking of stPCL-COOH to the chitosan network. Disc diffusion assay proved the antibacterial activity of chitosan hydrogel and composite hydrogel towards Escherichia coli as Gram-negative bacterium and Staphylococcus epidermidis as Gram-positive bacterium.
Kasetsart University. Office of the University Library
Address:
Bangkok
Email:
tdckulib@ku.ac.th
Name: Chantiga Choochottiros
Role:
Thesis Advisor
Created:
2019
Modified:
2025-08-03
Issued:
2025-08-03
วิทยานิพนธ์/Thesis
application/pdf
URL: https://www.lib.ku.ac.th/KUthesis/2562/natjaya-eka-all.pdf
CallNumber:
TP1180.P6 .N38
eng
DegreeName: Master of Science
Level: Master's Degree
Descipline: Nanomaterials Science
Grantor: Kasetsart University
©copyrights Kasetsart University
RightsAccess:
ใช้เวลา
0.039699 วินาที
Natjaya Ekapakul
| Title | Contributor | Type |
|---|---|---|
| Development of Chitosan-based hydrogel for biomedical applications
มหาวิทยาลัยเกษตรศาสตร์ Natjaya Ekapakul | Chantiga Choochottiros | วิทยานิพนธ์/Thesis |
| Chitosan-based composite hydrogel preparation and characterization
มหาวิทยาลัยเกษตรศาสตร์ Natjaya Ekapakul | Chantiga Choochottiros | วิทยานิพนธ์/Thesis |
Chantiga Choochottiros
| Title | Creator | Type and Date Create |
|---|---|---|
| Synthesis and characterization of novel unsaturated-PLA copolymers for using as toughening agent
มหาวิทยาลัยเกษตรศาสตร์ Chantiga Choochottiros;Wanvimol Pasanphan | Vachiravit Chalermpanaphan | วิทยานิพนธ์/Thesis |
| Development of Chitosan-based hydrogel for biomedical applications
มหาวิทยาลัยเกษตรศาสตร์ Chantiga Choochottiros | Natjaya Ekapakul | วิทยานิพนธ์/Thesis |
| Chitosan-based composite hydrogel preparation and characterization
มหาวิทยาลัยเกษตรศาสตร์ Chantiga Choochottiros | Natjaya Ekapakul | วิทยานิพนธ์/Thesis |
| Chitosan/Polycaprolactone Cryogel : effect of Polycaprolactone structure on physical
มหาวิทยาลัยเกษตรศาสตร์ Chantiga Choochottiros | Surisara Phangkam | วิทยานิพนธ์/Thesis |
| Fabrication and characterization of chitosanstar-shaped polycaprolactone network structure via ureaurethane Linkage
มหาวิทยาลัยเกษตรศาสตร์ Chantiga Choochottiros | Pennapa Amonkol | วิทยานิพนธ์/Thesis |