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Jureerat Saengrung. Effects of ribonucleotide supplementation on probiotic Bacillus subtilis growth modulation and the synergistic benefits for the health performance of Asian seabass (lates calcarifer). Master's Degree(Fishery Science and Technology). Kasetsart University. Office of the University Library. : Kasetsart University, 2023.
Effects of ribonucleotide supplementation on probiotic Bacillus subtilis growth modulation and the synergistic benefits for the health performance of Asian seabass (lates calcarifer)
Name: Jureerat Saengrung
Classification :.LCCS: SH167.S33
LCSH:
Sea basses
-- Feeding and feeds
LCSH:
Giant perch
LCSH:
Bacillus subtilis
LCSH:
Probiotics
LCSH:
Prebiotics
LCSH:
Nucleic acids
Abstract:
In aquaculture, due to the requirements for high-density culture, the diseases caused by bacterial pathogens have become a serious issue. To solve this problem, we performed symbiotic application of RNA and Bacillus subtilis as a sustainable and eco-friendly approach to improve the health and immunity of Asian seabass (Lates calcarifer) during cultivation without using any harmful antibiotics or chemicals. Among various forms of nucleic acids, such as mononucleotides and DNA, RNA was found to be most effective in promoting the growth performance of probiotic B. subtilis in all the tested minimal medium conditions. Accordingly, we used the symbiotic combination of B. subtilis and RNA for Asian seabass cultivation. After feed supplementation for fourteen days, the fish that received the combination treatment exhibited a significant increase in innate cellular and humoral immune parameters, including phagocytic activity, phagocytic index, respiratory burst, serum lysozyme and bactericidal activities, as well as upregulated expression of immunerelated genes, including HEPC1, A2M, C3, CC, CLEC, LYS, HSP70, and HSP90. Furthermore, significant increases were observed in the ileal villus height and goblet cell numbers. Histopathological abnormalities in the intestine and liver, suggesting that the synbiotic treatment is safe for use in fish. The treated Asian seabass also exhibited a significantly increased survival rate after Aeromonas hydrophila challenge. These results indicate that the synbiotic mixture of B. subtilis and RNA can be considered a beneficial feed additive and immunostimulant for Asian seabass cultivation.
Kasetsart University. Office of the University Library
Address:
Bangkok
Email:
tdckulib@ku.ac.th
Name: Prapansak Srisapoome
Role:
Thesis Advisor
Name: Xingguo Liang
Role:
Thesis CO-Advisor
Created:
2023
Modified:
2568-07-24
Issued:
2025-07-24
วิทยานิพนธ์/Thesis
application/pdf
URL: https://www.lib.ku.ac.th/KUthesis/2566/jureerat-sae-all.pdf
CallNumber:
SH167.S33 .J87
eng
DegreeName: Master of Science
Level: Master's Degree
Descipline: Fishery Science and Technology
Grantor: Kasetsart University
©copyrights Kasetsart University
RightsAccess:
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0.02562 วินาที
Jureerat Saengrung
| Title | Contributor | Type |
|---|---|---|
| Effects of ribonucleotide supplementation on probiotic Bacillus subtilis growth modulation and the synergistic benefits for the health performance of Asian seabass (lates calcarifer)
มหาวิทยาลัยเกษตรศาสตร์ Jureerat Saengrung | Prapansak Srisapoome | วิทยานิพนธ์/Thesis |
Prapansak Srisapoome
Xingguo Liang
| Title | Creator | Type and Date Create |
|---|