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Natsuda Manyagasa. The study of p-coumaric acid effects in chronic cerebral hypoperfusion rats. Master's Degree(Zoology). Kasetsart University. Office of the University Library. : Kasetsart University, 2019.
The study of p-coumaric acid effects in chronic cerebral hypoperfusion rats
Name: Natsuda Manyagasa
Classification :.LCCS: QL737.R666
LCSH:
Rats
-- Effect of p-coumaric acid
Abstract:
Oligemic energy failure and metabolic insufficiency initiate gradual neurodegeneration and cognitive impairments are the results of cerebral blood flow (CBF) reduction. We investigated the neuroprotective effects of p-coumaric acid (pCA) on neurodegeneration in association with cognitive impairments in rats with chronic cerebral hypoperfusion (CCH). Forty male Sprague-Dawley rats were randomly divided into 4 groups: Sham, BCCAO, BCCAO+50, and BCCAO+100. CCH was induced by modified 2-vessel occlusion (2VO) in the BCCAO groups. 50 and 100 mg/kg of pCA were given to BCCAO+50 and BCCAO+100, respectively, 24 h after finishing the 2VO surgery and continued for 3 weeks. The behavioral tests consisted of anxiety-like behavioral tested in an elevated plus maze (EPM) and hippocampal-dependent spatial learning and flexibility tested in a Morris water maze (MWM). Brain oxidative status, infarction, vulnerable hippocampus and corpus callosum (CC) white matter degeneration were evaluated. The results showed that modified 2VO induced reversible short-term anxiolytic-like behavior in the EPM (p < 0.05). These were found along with significant spatial learning and flexibility impairment (p < 0.05). Brain tissue analysis revealed that modified 2VO induced gradual change to brain oxidative status (p > 0.05) with significance reduce of infarction volume, vulnerable hippocampal CA1, CA3, DG and CC degeneration (p < 0.05). Additionally, 100 mg/kg of pCA significantly ameliorated the spatial learning and flexibility deficits, which coincided with the significant decreases of infarction volume, CA1, CA3 and CC degeneration (p < 0.05). We conclude that pCAs improving effects on spatial learning and flexibility deficits are neuro-protective against vulnerable neuronal and white matter degeneration in CCH rats.
Kasetsart University. Office of the University Library
Address:
Bangkok
Email:
tdckulib@ku.ac.th
Name: Wachiryah Thong-Asa
Role:
Thesis Advisor
Created:
2019
Modified:
2025-07-05
Issued:
2025-07-05
วิทยานิพนธ์/Thesis
application/pdf
URL: https://www.lib.ku.ac.th/KUthesis/2562/natsuda-man-all.pdf
CallNumber:
QL737.R666 .N27
eng
DegreeName: Master of Science
Level: Master's Degree
Descipline: Zoology
Grantor: Kasetsart University
©copyrights Kasetsart University
RightsAccess:
ใช้เวลา
0.039772 วินาที
Natsuda Manyagasa
| Title | Contributor | Type |
|---|---|---|
| The study of p-coumaric acid effects in chronic cerebral hypoperfusion rats
มหาวิทยาลัยเกษตรศาสตร์ Natsuda Manyagasa | Wachiryah Thong-Asa | วิทยานิพนธ์/Thesis |
Wachiryah Thong-Asa
| Title | Creator | Type and Date Create |
|---|---|---|
| The effect of p-coumaric acid on cerebral ischemia reperfusion injury in mice
มหาวิทยาลัยเกษตรศาสตร์ Wachiryah Thong-Asa | Romgase Sakamula | วิทยานิพนธ์/Thesis |
| Chronic cerebral hypoperfusion study in ICR mice
มหาวิทยาลัยเกษตรศาสตร์ Wachiryah Thong-Asa | Sirilak Somredngan | วิทยานิพนธ์/Thesis |
| Effect of beta-sitosterol in mice with trimethyltin-induced neurodegeneration
มหาวิทยาลัยเกษตรศาสตร์ Wachiryah Thong-asa | Nurinee Dolrahman. | วิทยานิพนธ์/Thesis |
| The study of p-coumaric acid effects in chronic cerebral hypoperfusion rats
มหาวิทยาลัยเกษตรศาสตร์ Wachiryah Thong-Asa | Natsuda Manyagasa | วิทยานิพนธ์/Thesis |
| Effect of alpha-mangostin and alpha-mangostin-loaded nanostructured lipid carriers on mice models of cerebral ischemia-reperfusion and Parkinsons disease
มหาวิทยาลัยเกษตรศาสตร์ Wachiryah Thong-Asa | Romgase Sakamola | วิทยานิพนธ์/Thesis |