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Shibata, Mai. B-sitosterol, campesterol and y-oryzanol as immune modulating agents. Master's Degree(Food Science). Kasetsart University. Office of the University Library. : Kasetsart University, 2018.
B-sitosterol, campesterol and y-oryzanol as immune modulating agents
Name: Shibata, Mai
Classification :.LCCS: QR181
LCSH:
Immune system
LCSH:
Macrophage
-- Activation
Abstract:
Immune modulating effects of three compounds found in rice bran oil; βsitosterol, campesterol and γ-oryzanol, were investigated using THP-1 macrophage cell model. β-sitosterol and campesterol belong to a group of phytosterols, while γoryzanol is not the case. γ-oryzanol is usually found in conjugated forms, which uniquely exists only in rice bran oil. Cytotoxicity was performed to examine the toxicity of phytosterols and γ-oryzanol and to provide proper working concentrations for gene expression analysis. A range of phytosterols and γ-oryzanol concentrations from 1-12 µM was assayed. The results showed that cytotoxicity was observed when concentrations of phytosterols and γ-oryzanol increased. Finally, final total concentration was chosen up to 2 µM to examine inflammatory gene expression analysis. β-sitosterol, campesterol and γ-oryzanol were tested as individuals up to 2 µM or as combinations at the final concentration also up to 2 µM. At resting stage, all test compounds showed no effect. At inflamed stage, β-sitosterol showed proinflammatory activity, while γ-oryzanol showed the tendency to inhibit expression of pro-inflammatory cytokine genes. Combinations of compounds were also analyzed at the concentration up to 2 µM. For the mixture of β-sitosterol, campesterol and γoryzanol, the results showed in the way that the immune modulating activities are not depended on the types of combination, but rather final total concentration. This research provides basic immunological information of various compounds found in rice bran oil on immune cells and comparing not only among individual phytosterols but also mixtures of phytosterols and γ-oryzanol.
Kasetsart University. Office of the University Library
Address:
Bangkok
Email:
tdckulib@ku.ac.th
Name: Wasaporn Chanput
Role:
Thesis Advisor
Name: Kriskamol Na Jom
Role:
Thesis CO-Advisor
Name: Pinthip Rumpagaporn
Role:
Thesis CO-Advisor
Created:
2018
Modified:
2025-07-02
Issued:
2025-07-02
วิทยานิพนธ์/Thesis
application/pdf
URL: https://www.lib.ku.ac.th/KUthesis/2561/mai-shi-all.pdf
CallNumber:
QR181 .S54
eng
DegreeName: Master of Science
Level: Master's Degree
Descipline: Food Science
Grantor: Kasetsart University
©copyrights Kasetsart University
RightsAccess:
ใช้เวลา
0.036801 วินาที
Shibata, Mai
| Title | Contributor | Type |
|---|---|---|
| B-sitosterol, campesterol and y-oryzanol as immune modulating agents
มหาวิทยาลัยเกษตรศาสตร์ Shibata, Mai | Wasaporn Chanput Kriskamol Na Jom | วิทยานิพนธ์/Thesis |
Wasaporn Chanput
| Title | Creator | Type and Date Create |
|---|---|---|
| B-sitosterol, campesterol and y-oryzanol as immune modulating agents
มหาวิทยาลัยเกษตรศาสตร์ Wasaporn Chanput;Kriskamol Na Jom | Shibata, Mai | วิทยานิพนธ์/Thesis |
| Immune stimulating activity of Okra polysaccharide on THP-1 macrophages
มหาวิทยาลัยเกษตรศาสตร์ Wasaporn Chanput | Thanathon Trakoolpolpruek | วิทยานิพนธ์/Thesis |
Kriskamol Na Jom
Pinthip Rumpagaporn
| Title | Creator | Type and Date Create |
|---|---|---|
| Antioxidant and prebiotic properties of oligosaccharides extracts from commercially defatted rice bran
มหาวิทยาลัยเกษตรศาสตร์ Pinthip Rumpagaporn | Fitriani, Dwita Ratih | วิทยานิพนธ์/Thesis |
| Development of instant Mung Bean vermicelli production by microwave and extrusion technologies
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| Effect of autoclaving-cooling treatment on resistant starch content and antioxidant Activity of unripe banana flour and its application in instant soup powder supplemented with kale powder
มหาวิทยาลัยเกษตรศาสตร์ Pinthip Rumpagaporn | Warintorntip Pakjirasirikul | วิทยานิพนธ์/Thesis |