Physiochemical characterization and biocompatibility of porous bioglass-calcium phosphatebiopolymers composite scaffolds for bone tissue engineering application

Name: Sukanya Mooyen

LCSH: Kasetsart University -- Dissertations. Ph.D. (Physics) 2018

Classification :.LCCS: QC173.4.C63

LCSH: Kasetsart University. -- Department of Physics -- Dissertations

LCSH: Composite materials

LCSH: Bioactive glasses

LCSH: Tissue scaffolds

LCSH: Biomedical materials

LCSH: Bone regeneration

LCSH: Tissues -- Mechanical properties

LCSH: Tissue engineering

Abstract: In the present study, scaffolds for bone tissue engineering applications were made by immersing the inorganic phases those consist of calcium phosphate (CaPs) mixing bioactive glass (BG) with polycaprolactone (PCL) as a binder in an organic phase of first part, chitosan/collagen matrix (CaPBG@ChiCol) and second part, chitosan/Alginate matrix (CaPBG@ChiAlginate). In the first part, we synthesized the composite scaffolds by mixing of CaPBG/PCL ratio was 1:1.5 wt/wt and then to varying the ratio of Chitosan/Collagen ratio was 1:1 wt/wt. In the second part, we choose the inorganic (biphasic calcium phosphate:PCL)-organic (ChiAlginate) composite scaffolds at two ratio were 0.5:1 wt/wt and 1:1 wt/wt between inorganic (powder)/organic (liquid). And then, to varying the ratio of Chitosan/Alginate at three ratio are 1:2 wt/wt, 1:1 wt/wt and 2:1 wt/wt. The porous scaffolds were obtained by freeze drying the combinations. The mechanical properties and in vitro growth of rat osteoblast-like UMR-106 cells were investigated. The investigation from the first part indicated that the compressive strength was controlled by the types of CaP. The highest compressive strength of the composites was BCP. And then, in the second part the composite scaffolds that consist of the inorganic-organic ratio at 1:1 wt/wt and the Chitosan/Alginate ratio at 1:2 wt/wt have the best mechanical and biological properties having the better potential for application in bone tissue engineering.

Kasetsart University. Office of the University Library

Address: Bangkok

Email: tdckulib@ku.ac.th

Name: Weeraphat Pon-on

Role: Thesis Advisor

Created: 2018

Modified: 2025-06-29

Issued: 2025-06-29

วิทยานิพนธ์/Thesis

application/pdf

URL: https://www.lib.ku.ac.th/KUthesis/2561/sukanya-moo-all.pdf

CallNumber: QC173.4.C63 .S85

eng

DegreeName: Doctor of Philosophy

Level: Doctoral Degree

Descipline: Physics

Grantor: Kasetsart University

©copyrights Kasetsart University

ลำดับที่.	ชื่อแฟ้มข้อมูล	ขนาดแฟ้มข้อมูล	จำนวนเข้าถึง	วัน-เวลาเข้าถึงล่าสุด
1	sukanya-moo-all.pdf	10.99 MB

ใช้เวลา

0.030017 วินาที