Natpreeya Premjaroen. Utility of using cardiac biomarkers on staging of feline hypertrophic cardiomyopathy. Master's Degree(Veterinary Clinical Studies). Kasetsart University. Office of the University Library. : Kasetsart University, 2023.
Utility of using cardiac biomarkers on staging of feline hypertrophic cardiomyopathy
Abstract:
Hypertrophic cardiomyopathy is the most common heart disease in cats. Clinical signs vary from subclinical to life-threatening associated with congestive heart failure (CHF) and arterial thromboembolism (ATE). The objective of this study was to distinguish between B1-, B2-, and C-staged HCM cats by using parameters obtained from thoracic radiographs, cardiac biomarkers, and combination tests. This study was performed in 72 cats with an age of 1-7 years. The weight, sex, and breed of all cats were similar. Echocardiography was used as a gold standard to diagnose cardiac disease and separate the cats into 4 groups, healthy control (n=21), HCM B1 (n=16), HCM B2 (n=12), and HCM C (n=23). All cats underwent right lateral recumbent and DV/VD radiographic views, and the ten parameters; L-VHS, DV/VDVHS, L-CLA, DV/VD-CLA, L-CSA, DV/VD-CSA, LA-VHS, CRT, LW and LW /S4 were measured. Determine the serum concentrations of NT-proBNP, cTnI, SAA, and ADMA and find the optimal cutoff point in each stage of HCM. This study recommends the serial testing of the DV/VD-CLA ≥ 5.41 + serum NT-ProBNP concentration ≥ 606 pmol/L because they provide good sensitivity and specificity, suitable to be a screening method for diagnosing HCM C cats. The serial testing of the LW / S4 >12.85 + serum NT-ProBNP concentration ≥ 105.7 pmol/L was recommended to be a screening method for diagnosing HCM B2 cats
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