Evaluation of liver profiles in dogs with hyperadrenocorticism after treatment with trilostane

Name: Nannicha Tinted

LCSH: Kasetsart University -- Theses. M.S. (Veterinary Clinical Studies) 2023.

Classification :.LCCS: SF992.E53

LCSH: Kasetsart University. -- Faculty of Veterinary Medicine -- Theses.

LCSH: Dogs -- Endocrinology.

LCSH: Dogs -- Diseases.

LCSH: Veterinary pathology.

LCSH: Hyperadrenocorticism

Abstract: Hyperadrenocorticism (HAC) often leads to vacuolar hepatopathy. The impact of trilostane treatment on serum total bile acids (SBAs) concentrations in dogs with HAC remains unknown. This study investigated SBAs concentrations in healthy dogs and those with HAC following trilostane therapy. Ten healthy dogs and fifteen dogs with HAC were prospectively enrolled. A biochemistry profile and pre- and post-prandial SBAs concentrations were determined in each dog. Dogs with HAC were reassessed at 1 and 3 months after the initiation of trilostane treatment. Dogs with HAC had significantly higher serum ALT, ALP, and GGT activities, and cholesterol, triglyceride, and pre-prandial SBAs concentrations compared to healthy dogs. After 3 months of trilostane treatment, polyuria/polydipsia and polyphagia were completely resolved in 42.8% and 35.7%, respectively. Significant improvements in serum ALT and ALP activities and cholesterol concentrations were observed within 1–3 months of trilostane treatment. However, pre- and post-prandial SBAs concentrations did not significantly decrease. These findings suggest that treatment with low-dose trilostane for 3 months appears to reduce serum liver enzyme activities, but not SBAs concentrations. Further investigation is warranted to explore the effects of low-dose trilostane treatment on SBAs concentrations for a longer duration or after achieving appropriate post-ACTH cortisol levels.

Kasetsart University. Office of the University Library

Address: Bangkok

Email: tdckulib@ku.ac.th

Name: Sathidpak Assawarachan

Role: Thesis Advisor

Created: 2023

Modified: 2025-06-24

Issued: 2025-06-24

วิทยานิพนธ์/Thesis

วิทยานิพนธ์/Thesis

application/pdf

URL: http://www.lib.ku.ac.th/KUthesis/2566/nannicha-tint-all.pdf

CallNumber: SF992.E53.N36

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Veterinary Clinical Studies

Grantor: Kasetsart University

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