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Panyawarin Soommat. Investigating light-induced metabolic responses of Cordyceps militaris using transcriptome integrated genome-scale modeling. Master's Degree(Genetic Engineering and Bioinformatics). Kasetsart University. Office of the University Library. : Kasetsart University, 2022.
Investigating light-induced metabolic responses of Cordyceps militaris using transcriptome integrated genome-scale modeling
Name: Panyawarin Soommat
Classification :.LCCS: QK623.C55
LCSH:
Cordyceps
LCSH:
Computational biology
LCSH:
Metabolism
Abstract:
Genome-scale metabolic model (GSMM) of Cordyceps militaris has provided a comprehensive basis on carbon assimilation for cell growth and metabolite production. However, the GSMM remains unable to probe the lightinduced metabolic responses of C. militaris. Thus, the aim of this study is to investigate light-induced metabolic responses of C. militaris using transcriptome integrated GSMM. As a result, GSMM of C. militaris, called iPS1474, was enhanced which contained 1,474 genes, 1,245 metabolites and 1,916 metabolic reactions. Additionally, the iPS1474 using Gene Inactivity Moderated by Metabolism and Expression (GIMME), observably, the simulated results of iTGSMM-iPS1474-P50 agreed well with phenotypic data under light-sucrose condition and showed flux distribution which improved the predicted fluxes through the carotenoid biosynthesis. Moreover, the common gene-associated reaction reveals the light-induced metabolic responses in consistent with the expressed genes-associated reactions of the culture using different carbon sources. This study provides a useful perspective in manipulating the metabolic genes and fluxes towards the target metabolite productions.
Kasetsart University. Office of the University Library
Address:
Bangkok
Email:
tdckulib@ku.ac.th
Name: Wanwipa Vongsangnak
Role:
Thesis Advisor
Name: Kobkul Laoteng
Role:
Thesis Co-Advisor
Name: Teeraphan Laomettachit
Role:
Thesis Co-Advisor
Created:
2022
Modified:
2025-06-24
Issued:
2025-06-24
วิทยานิพนธ์/Thesis
application/pdf
URL: https://kasetsart.idm.oclc.org/login?url=http://www.lib.ku.ac.th/KUthesis/2565/panyawarin-soom-all.pdf
CallNumber:
QK623.C55.P36
eng
DegreeName: Master of Science
Level: Master's Degree
Descipline: Genetic Engineering and Bioinformatics
Grantor: Kasetsart University
©copyrights Kasetsart University
RightsAccess:
ใช้เวลา
0.03165 วินาที
Panyawarin Soommat
| Title | Contributor | Type |
|---|---|---|
| Investigating light-induced metabolic responses of Cordyceps militaris using transcriptome integrated genome-scale modeling
มหาวิทยาลัยเกษตรศาสตร์ Panyawarin Soommat | Wanwipa Vongsangnak Kobkul Laoteng Teeraphan Laomettachit | วิทยานิพนธ์/Thesis |
Wanwipa Vongsangnak
Kobkul Laoteng
| Title | Creator | Type and Date Create |
|---|---|---|
| Construction of Regulatory Network in Fatty Acid Desaturation of Mucor rouxii via Computational Approach
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าธนบุรี Supapon Cheevadhanarak;Kobkul Laoteng;สุภาภรณ์ ชีวะธนรักษ์;กอบกุล เหล่าเท้ง | Pinnarat Rattanavisud พิณรัตน์ รัตนวิสุทธิ์ | วิทยานิพนธ์/Thesis |
| Investigating light-induced metabolic responses of Cordyceps militaris using transcriptome integrated genome-scale modeling
มหาวิทยาลัยเกษตรศาสตร์ Wanwipa Vongsangnak;Kobkul Laoteng;Teeraphan Laomettachit | Panyawarin Soommat | วิทยานิพนธ์/Thesis |
| Investigation of transcriptional responses of cordyceps militaris to different temperatures
มหาวิทยาลัยเกษตรศาสตร์ Wanwipa Vongsangnak;Kobkul Laoteng | Patthanaphon Lusakunwiwat | วิทยานิพนธ์/Thesis |
| Integrative analysis of phenotypic traits and transcriptomes between mucor circinelloides strains for lipid production
มหาวิทยาลัยเกษตรศาสตร์ Wanwipa Vongsangnak ;Kobkul Laoteng | Li, Fanyue | วิทยานิพนธ์/Thesis |
Teeraphan Laomettachit