Wound dressing in the combination of cellulose nanocrystal-reinforced polyvinyl alcohol and gum tragacanth

Name: Diem, Luong Ngoc

LCSH: Kasetsart University -- Theses. M.S. (Biotechnology) 2022.

Classification :.LCCS: TP248.65.C45

LCSH: Kasetsart University. -- Department of Biotechnology -- Theses.

LCSH: Cellulose.

LCSH: Cellulose nanocrystals.

LCSH: polyvinyl alcohol.

LCSH: Biomedical materials.

LCSH: Wound healing.

Abstract: Biomaterial based wound dressing was fabricated by utilizing cellulose nanocrystals (CNCs) as nano-filler in polymeric mixture, which was produced via solution casting of poly(vinyl alcohol) (PVA) and gum tragacanth (GT). The changes in physical and chemical characteristics of neat PVA, PVA/GT and PVA/GT/CNC films with varying concentration of CNCs (2 to 10 %) were observed. CNCs through acid hydrolysis formed a viscous aqueous solution that consisted of individual and aggregated nanosize particles. Scanning electron microscopy (SEM) illustrated cluster formation of CNCs on the polymer matrix. The chemical functional groups in the material were confirmed by Fourier transform infrared (FTIR) spectrometer. The GT and CNCs in the polymer matrix improved the water uptake and prolonged stability for 7 days, with maximum swelling ratio of 260% in the neat PVA. Additionally, CNCs incorporation enhanced tensile strength from 54.63 MPa to 80.39 MPa. The biological properties of PVA/GT/CNC were analyzed, which showed that the dressing material is nontoxic to mouse fibroblast cells L929 and exhibited excellent antibacterial activities against Staphylococcus aureus DMST 8840 and Pseudomonas aeruginosa TISTR 781, indicating that composite film is suitable for application in wound dressing.

Kasetsart University. Office of the University Library

Address: Bangkok

Email: tdckulib@ku.ac.th

Name: Prakit Sukyai

Role: Thesis Advisor

Created: 2022

Modified: 2025-06-23

Issued: 2025-06-23

วิทยานิพนธ์/Thesis

วิทยานิพนธ์/Thesis

application/pdf

URL: https://kasetsart.idm.oclc.org/login?url=http://www.lib.ku.ac.th/KUthesis/2565/luong-ngo-all.pdf

CallNumber: TP248.65.C45.D54

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Biotechnology

Grantor: Kasetsart University

©copyrights Kasetsart University

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