The elucidation of underlying mechanisms associated with neuroprotective effects of selected plant-derived function ingredients in Caenorhabditis Elegans

Elucidation of underlying mechanisms associated with neuroprotective effects of selected plant-derived function ingredients in Caenorhabditis Elegans

Name: Nurulhusna Awaeloh

Address: 333 Moo1, Thasud, Muang, Chiang Rai 57100

Organization : Mae Fah Luang University

Email : library@mfu.ac.th

keyword: Curcuma longa L.

MeSH: Microencapsulation -- 314931

Classification :.DDC: e-thesis

; Microencapsulation

MeSH: Antioxidants -- 314711

MeSH: Parkinson's disease -- 314932

MeSH: Caenorhabditis elegans -- 314933

LCSH: Microencapsulation -- 314931

LCSH: Antioxidants -- 314711

LCSH: Parkinson's disease -- 314932

LCSH: Caenorhabditis elegans -- 314933

Abstract: Neurodegenerative diseases, such as Parkinson’s disease (PD) are characterized by a progressive decline in nervous system function. These conditions are becoming increasingly prevalent worldwide, including in Thailand, primarily due to age-related degeneration and limited treatment options. Reducing oxidative stress is a promising approach to prevent and slow disease progression, with plant-based antioxidants showing significant potential. This study evaluated the antioxidant potential of medicinal plants approved by the Thai Food and Drug Administration (FDA), focusing on microencapsules containing a standardized extract of Curcuma longa L. Caenorhabditis elegans (C. elegans) was used as a model organism to investigate the neuroprotective mechanism of curcumin microencapsulated against 6-hydroxydopamine (6-OHDA)-induced dopaminergic (DA) neurodegeneration, and their applicability in the food industry was tested by incorporating them into ready-to-eat extruded snacks. The results showed that Curcuma longa is a locally medicinal plant that has demonstrated a strong neuroprotective effect and a good antioxidant capacity in a systematic review. It also high levels of phenolic and flavonoid compounds, exhibiting strong antioxidant activity through various mechanisms. Microencapsulation (sCL11064) preserved these properties without toxicity, as the sCL11064 did not effects on feeding behavior test, although there are still limitations in concentrations that have not yet shown positive findings, it demonstrated neuroprotective effects against neurodegeneration in dopamine neurons induced by 6-OHDA. Additionally, functional foods made from unripe banana flour and fortified with sCL11064 represent a novel product with high consumer acceptance. These results highlight the potential of antioxidant-enriched functional foods for promoting neurological health. However, further study is required to determine its in vivo antioxidant efficacy, including superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) levels, as well as neuroprotective testing in rodent models and clinical trials.

Mae Fah Luang University. Learning Resources and Educational Media Centre

Address: CHIANG RAI

Email: library@mfu.ac.th

Name: Sasitorn Chusri

Role: Advisor

Created: 2024

Modified: 2025-06-17

Issued: 2025-06-17

วิทยานิพนธ์/Thesis

application/pdf

CallNumber: e-thesis

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Health and Biomedical Analytics

Grantor: Mae Fah Luang University

©copyrights Mae Fah Luang University

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