Modification of electrodes for detection of dopamine

Name: Tharaton Nooin

Address: 333 Moo1, Thasud, Muang, Chiang Rai 57100

Organization : Mae Fah Luang University

Email : library@mfu.ac.th

keyword: Square-wave Voltammetry

MeSH: Dopamine -- 311611

Classification :.DDC: e-thesis

; Screen-printed Gold Electrode

MeSH: Square waves -- 311612

MeSH: Voltammetry -- 311613

MeSH: Carbon, Activated -- 311614

MeSH: Activated Screen process printing -- 311615

MeSH: Serigraphy -- 311616

LCSH: Dopamine -- 311611

LCSH: Square waves -- 311612

LCSH: Voltammetry -- 311613

LCSH: Carbon, Activated -- 311614

LCSH: Activated Screen process printing -- 311615

Abstract: Dopamine, a neurotransmitter compound, is associated with several important diseases of the nervous system such as Parkinson's disease, depression, and schizophrenia. Dopamine in the blood can be detected by several methods. The square-wave voltametric analysis is one of the methods of choice for dopamine determination. However, this method of analysis of dopamine in the blood is hindered by interference from ascorbic acid and uric acid. The oxidation peak of dopamine on most solid electrodes appears at about the same potential as the aforementioned acids. In this study, a modified electrodes based on activated carbon powder coated on a gold screen-printed electrode (SPGE), consisting of magnetic carbon (MC/SPGE) and porous carbon (PC/SPGE), and porous carbon coated with Nafion were prepared and used for dopamine detection. The prepared electrodes enhanced the responses for dopamine and suppressed the interfering effect from uric acid and ascorbic acid. The modified electrode showed good linear ranges of 5 -1750 μM (R2 = 0.991) for PC/SPGE coated with Nafion, 5-1750 μM (R2 = 0.991) for PC/SPGE, 5-1250 μM (R2 = 0.972) for MC/SPGE. The detection limit of 0.87μM, 1.14 μM, and 1.48 μM for PC/SPGE, PC/SPGE coated with Nafion, and MC/SPGE, respectively (scan rate of 100 mV/s, amplitude of 0.04 V, frequency of 50 Hz and e-step potential of 0.01 V). Analysis of dopamine in blood samples confirmed the ability of these modified electrodes for dopamine detection.

LCSH: Serigraphy -- 311616

Mae Fah Luang University. Learning Resources and Educational Media Centre

Address: CHIANG RAI

Email: library@mfu.ac.th

Name: Prachak Inkaew

Role: Advisor

Created: 2024

Modified: 2024-12-20

Issued: 2024-12-20

วิทยานิพนธ์/Thesis

application/pdf

CallNumber: e-thesis

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Applied Chemistry

Grantor: Mae Fah Luang University

©copyrights Mae Fah Luang University

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