CFD analysis on the performance of a DPI

Name: Al-Waked, R. F.

Organization : German Jordanian University. Department of Mechanical and Maintenance Engineering

Email : rafat.alwaked@gju.edu.jo

Name: Dahab, T. Abu

Organization : German Jordanian University. Department of Mechanical and Maintenance Engineering

keyword: Inhalation drug delivery

LCSH: Lungs -- Analysis

; Dry powder inhaler

LCSH: Computational fluid dynamics

Abstract: Effects of inhalation flow rate, mouthpiece length and mouthpiece shape on the performance of the dry powder inhaler (DPI) were investigated. Initial quantification of flow turbulence levels and flow fields generated within the were examined using computational fluid dynamics (CFD) approach. The CFD model was validated against available published works in literature. Results showed that the length of the mouthpiece determines the level of flow development through the mouthpiece itself and does not affect the flow at the base of the inhaler. Also, as the length of the mouthpiece decreases a non-uniform behaviour existed at the outlet of the inhaler where regions of high velocity were presented thus an overall decrease in the performance of the inhaler. As the inhalation flow rate increases the level of turbulence in the device increases and reaching a maximum at the grid. This study showed that the geometry of a dry powder inhaler mouthpiece could have a significant effect on the amount of throat deposition produced and the flow development when using the device by controlling the exit air flow velocity.

King Mongkut's University of Technology North Bangkok. Central Library

Address: BANGKOK

Email: library@kmutnb.ac.th

Created: 2024

Modified: 2024-12-16

Issued: 2024-12-16

บทความ/Article

application/pdf

BibliograpyCitation : In Thai Society of Mechanical Engineers (TSME) and Chiang Mai University. The 13th TSME International Conference on Mechanical Engineering (TSME-ICoME 2023) (pp.363-372). Chiang Mai : Chiang Mai University, 2023

eng

©copyrights King Mongkut's University of Technology North Bangkok

ลำดับที่.	ชื่อแฟ้มข้อมูล	ขนาดแฟ้มข้อมูล	จำนวนเข้าถึง	วัน-เวลาเข้าถึงล่าสุด
1	TSME-ICoME13 2023pp.363-372.pdf	847.31 KB

ใช้เวลา

0.03669 วินาที