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Suthida Boonsith. Development and characterization of amidated pectin-PVA hydrogels for enhanced drug delivery and antimicrobial properties. (). King Mongkut's University of Technology North Bangkok. Central Library. : , 2024.
Development and characterization of amidated pectin-PVA hydrogels for enhanced drug delivery and antimicrobial properties
Name: Supatcha Suankhem
Organization :
Mahidol University. Faculty of Engineering
Name: Woranart Jonglertjunya
Organization :
Mahidol University. Faculty of Engineering
Organization :
Mahidol University. Faculty of Engineering
Name: Suthida Boonsith
Organization :
Mahidol University. Faculty of Engineering
LCSH:
Pectin
LCSH:
Polyvinyl alcohol
LCSH:
Nanogels
Abstract:
Hydrogel-based drug delivery systems have gained significant attention due to their unique properties
and applications. In this study, hydrogels were prepared from polyvinyl alcohol (PVA), pectin (Pec)-PVA,
and amidated pectin (AMDP)-PVA for potential drug delivery and antimicrobial applications. Pectin was
extracted from pomelo peel through acid extraction, and amidation was carried out using ethanolamine. The
hydrogels were created using a freeze-thaw (FT) cycle, with varying freezing times of 24, 48, and 72 hours.
The FT cycle duration had a significant impact on the hydrogels' properties. The swelling behavior of the
hydrogel at different FT cycles and types was thoroughly investigated. Furthermore, loading and release
studies were conducted by using Chlorhexidine as a model drug, revealing that AMDP-PVA hydrogels
exhibited superior loading and release profiles compared to PVA and Pec-PVA hydrogels. These findings
emphasized the potential of amidated pectin as a valuable component for controlled drug delivery systems.
To assess their suitability for biomedical applications, the antimicrobial properties of these hydrogels were
evaluated against E. coli and S. aureus. This study emphasized the importance of modifying hydrogel
characteristics by selecting appropriate constituents and processing conditions for drug delivery applications
and the potential of amidated pectin-PVA hydrogels in the field of pharmaceutical and medical research
King Mongkut's University of Technology North Bangkok. Central Library
Address:
BANGKOK
Email:
library@kmutnb.ac.th
Created:
2024
Modified:
2024-12-09
Issued:
2024-12-09
บทความ/Article
application/pdf
BibliograpyCitation :
In Kasetsart University. Faculty of Science. The Pure and Applied Chemistry International Conference 2024 (PACCON 2024) (pp.958-965). Bangkok : Kasetsart University, 2024
eng
©copyrights King Mongkut's University of Technology North Bangkok
RightsAccess:
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0.035304 วินาที
Supatcha Suankhem
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