Square wave voltammetry on a modified screen-printed electrode for selective detection of dopamine in the presence of uric acid

Name: Tharaton Nooin

Organization : Mae Fah Luang University. Center of Chemical Innovation for Sustainability (CIS)

Email : 6551102001@lamduan.mfu.ac.th

Name: Thaneeya Hawiset

Organization : Mae Fah Luang University. School of Medicine

Name: Prachak Inkaew

Organization : Mae Fah Luang University. Center of Chemical Innovation for Sustainability (CIS)

keyword: Square wave voltammetry

LCSH: Dopamine -- Analysis

LCSH: Uric acid -- Analysis

LCSH: Electrochemical analysis

Abstract: Dopamine, a neurotransmitter compound, is associated with several important diseases of the nervous system such as Parkinson's disease, depression, and schizophrenia. Dopamine in the blood can be detected by several methods. The square-wave voltammetric analysis is one of the methods of choice for dopamine determination. However, this method of analysis of dopamine in the blood is hindered by interference from ascorbic acid and uric acid; the oxidation peak of dopamine on most solid electrodes appears at about the same potential as the aforementioned acids. In this study, a modified electrode based on activated carbon powder coated on a screen-printed gold electrode was prepared and used for dopamine detection. The prepared electrode enhanced the responses for dopamine and suppressed the interfering effect from uric acid. The modified electrode showed a good linear range of 0.50 – 800.0 μM (R2 = 0.998) with a detection limit (S/N = 3) of 0.36 μM (scan rate of 100 mV/s, amplitude of 0.04 V, frequency of 50 Hz and e-step potential of 0.01 V). Analysis of dopamine in blood samples confirmed the ability of this modified electrode for dopamine detection. The concentrations of dopamine in blood samples obtained from square-wave voltammetric analysis were in good agreement with the values obtained from UV-visible spectroscopy

King Mongkut's University of Technology North Bangkok. Central Library

Address: BANGKOK

Email: library@kmutnb.ac.th

Created: 2024

Modified: 2024-11-25

Issued: 2024-11-25

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BibliograpyCitation : In Kasetsart University. Faculty of Science. The Pure and Applied Chemistry International Conference 2024 (PACCON 2024) (pp.51-55). Bangkok : Kasetsart University, 2024

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