Effects of nano beta-tricalcium phosphate particles on microstructure and physicochemical properties of thermosensitive chitosan/collagen hydrogel

Name: Maytha Sareethammanuwat

Organization : Thammasat University Rangsit campus. Faculty of Dentistry

Name: Tossapon Phromsatit

Organization : Thammasat University Rangsit campus. Faculty of Science and Technology

Name: Supakorn Boonyeun

Organization : Thammasat University Rangsit campus. Faculty of Science and Technology

Name: Premjit Arpornmaeklong

Organization : Thammasat University Rangsit campus. Faculty of Dentistry

Email : pramejid@gmail.com

ThaSH: Spectrum analysis

ThaSH: Chitosan

ThaSH: Nanoparticles

ThaSH: Nanogels -- Synthesis

Abstract: Thermosensitive hydrogel is easy to use and decreases donor site morbidity. The current study aimed to investigate effects of beta-tricalcium phosphate nanoparticles (bTCP) on microstructure and physicochemical properties of bTCP-b-glycerophosphate-chitosan/collagen hydrogel (bTCP-bGP-Ch/Col). Beta-TCP nanoparticles, 1 percent, 2 percent and 3 percent (w/v), were incorporated into hydrogel and then sol-gel transition of the hydrogel was activated by bGP at 37 degrees. It was found that the addition of bTCP could stabilize pH values during the sol-gel process. Scanning electron microscope (SEM) demonstrated well-defined porous structure of the hydrogel with homogenous deposition of bTCP nanoparticles along the porous walls. Median pore size of the hydrogels was 100-200 μm. A detection of calcium from an energy-dispersive (EDS) analysis further confirmed a presence of bTCP within the matrix. Based on Fourier-Transform Infrared Spectroscopy (FT-IR) analysis, the N-H bending vibration band (1541 cm-1) in atelocollagen spectrum shifted to a higher frequency (1560 cm-1) in bTCP-bGP-Ch/Col hydrogel. The analysis suggested a formation of intermolecular electrostatic attractions among bGP-Ch/Col matrix. A high concentration of bTCP was found relating to low porosity and permeability of the hydrogels.

King Mongkut's University of Technology North Bangkok. Central Library

Address: BANGKOK

Email: library@kmutnb.ac.th

Created: 2020

Modified: 2024-10-16

Issued: 2024-10-16

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BibliograpyCitation : In the Chemical Society of Thailand under the Patronage of Professor Dr. HRH Princess Chulabhorn in association, Thammasat University Faculty of Science and Technology. The Pure and Applied Chemistry International Conference 2020 (PACCON 2020) (MN133-138). Bangkok : Thammasat University

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