Thun Kusirisin. Clinical efficacy of polycaprolactone membrane for bone augmentation in dental implant treatment : a pilot study. Master's Degree(Dentistry). Thammasat University. Thammasat University Library. : Thammasat University, 2022.
Clinical efficacy of polycaprolactone membrane for bone augmentation in dental implant treatment : a pilot study
Abstract:
Polycaprolactone (PCL), is a biodegradable biomaterial that can be used to promote cell proliferation and differentiation. This study aimed to compare the clinical efficacy between a newly developed bilayered polycaprolactone (PCL) membrane with a CytoplastTM RTM collagen membrane for guided bone regeneration (GBR) with simultaneous implant placement. Twenty-four patients were randomized to test group (PCL) or control group (RTM). Primary outcomes were buccal bone thickness (BBT) immediately postimplantation and at 6-months using cone-beam CT and soft tissue surface dimensional changes (STC) at crown insertion, 6-months, and 1- year after loading using intraoral scanner. Secondary outcomes included clinical parameters, healing index, implant stability, pink esthetic score and marginal bone levels. The augmented alveolar ridge was evidently success in both groups while slightly resorbed at 6-months follow-up. The percentage of reduced BBT were 32.38, 25.94, and 23.96% in the test group and 34.42, 14.75, and 6.34% in the control group at 0, 2, and 4 mm from implant shoulder. Minimal loss of STC was observed in both groups up to 1 year of loading. No statistically significant difference was found between two groups in all assessed outcomes (p > 0.05). Bilayered PCL membrane was safe and effective for GBR with implant placement
Thammasat University. Thammasat University Library