The comparative study of the effectiveness in treating back acne between 0005% vitamin D analogue and 0025% vitamin A cream

Name: Siwadol Loetphornphawit

keyword: Back Acne

MeSH: Acne

Classification :.DDC: e-Theses

; Acne Vulgaris

MeSH: Vitamin A

MeSH: Vitamin D

MeSH: Acne -- Treatment -- 296030

LCSH: Acne

LCSH: Vitamin A

LCSH: Vitamin D

LCSH: Acne -- Treatment -- 296030

Abstract: Acne is a disease of the pilosebaceous follicle and one of the most common chronic skin disorders. There are multiple factors that causes acne; such as increased sebum production, alteration of the quality of sebum lipids, inflammatory processes, dysregulation of the hormone microenvironment, interaction with neuropeptides, follicular hyperkeratinization and the proliferation of Propionibacterium acnes within the follicle. Back acne, and other forms of acne, occur when pores become clogged, which happens when sebum oil, skin cells, and P. Acnes bacteria build up inside the pores. P. acnes activates the innate immunity via the expression of protease activated receptors (PARs), tumour necrosis factor (TNF) a and toll-like receptors (TLRs), and the production of interferon (INF) c, interleukins (IL-8, IL12, IL-1) and matrix metalloproteinases (MMPs) by keratinocytes, resulting in the hyper keratinization of the pilosebaceous unit. Recently, Vitamin D (Calcipotriene) is an important regulator of immune function and largely acts to dampen chronic inflammatory events in a variety of tissues. It appears to have systemic antimicrobial and other effects that may be crucial in a variety of both acute and chronic illnesses. The study also showed that Vitamin D (Calcipotriene) can reduce the inflammatory process Topical retinoid is the first line in the treatment of mild-to-moderate acne. Retinoid are vitamin A derivatives, which inhibit the formation of noninflammatory micro-comedones and inflammatory and lesions, as well as decrease the number of lesions. Retinoid also exhibit direct anti-inflammatory activity. The advantage of a topical retinoid over a systemic retinoid is its site specificity. This allows treatment of cutaneous lesions without inducing the various adverse effects of systemic retinoids. The major adverse effect of topical retinoids is local irritation including dry skin, discomfort, erythema, and scaling.

Mae Fah Luang University. Learning Resources and Educational Media Center

Address: CHIANG RAI

Email: library@mfu.ac.th

Name: Rassapoom Sumaetheiwit

Role: Advisor

Created: 2023

Modified: 2024-01-18

Issued: 2024-01-18

วิทยานิพนธ์/Thesis

application/pdf

CallNumber: e-Theses

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Dermatology

Grantor: Mae Fah Luang University

©copyrights Mae Fah Luang University

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