Chemometrics-assisted UV spectrophotometric methods for simultaneous determination of amlodipine besylate and valsartan in pharmaceutical tablets

Name: Nidthida Archeepsudjarit

Organization : Mahidol University. Faculty of Pharmacy

Email : nidthida.arc@mahidol.ac.th

Name: Supavadee Timum

Organization : Mahidol University. Faculty of Pharmacy

ThaSH: Spectrophotometry

ThaSH: Drugs -- Analysis

ThaSH: Biological assay

ThaSH: Spectrum analysis -- Instruments

Abstract: Amlodipine besylate and valsartan are used in combination for treatment of hypertension. The standard quality control method for determination of their contents is high-performance liquid chromatography. In this study, two chemometrics procedures, principle component regression (PCR) and partial least square regression (PLS), utilizing UV absorption were developed to use as alternative method for assaying of such drugs in pharmaceutical tablets. PLS models of both drugs were superior more than PCR models. The successive PLS methods were used UV absorbance data between 300-400 nm for amlodipine besylate with the latent factor 1 and 200-300 nm with the latent factors 3 for valsartan. The application in pharmaceutical tablets was acceptable.

King Mongkut's University of Technology North Bangkok. Central Library

Address: BANGKOK

Email: library@kmutnb.ac.th

Created: 2020

Modified: 2023-11-22

Issued: 2023-11-22

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BibliograpyCitation : In the Chemical Society of Thailand under the Patronage of Professor Dr. HRH Princess Chulabhorn in association, Thammasat University Faculty of Science and Technology. The Pure and Applied Chemistry International Conference 2020 (PACCON 2020) (AC29-34). Bangkok : Thammasat University

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