A Study of efficacy of topical grapeseed oil for reducing wrinkle on periorbital areas in asian populations

Study of efficacy of topical grapeseed oil for reducing wrinkle on periorbital areas in asian populations

Name: Prajitno, Cherish Romina

keyword: Pure (100%) Grapeseed Oil

MeSH: Grape seed oil -- 306326

Classification :.DDC: e-Theses

; Periorbital Wrinkles

MeSH: Skin -- Wrinkles

LCSH: Grape seed oil -- 306326

LCSH: Skin -- Wrinkles

Abstract: Background: There is 2 factor that cause the wrinkles in the human. They are Intrinsic factor and extrinsic factor. Antioxidants play as the main role for inhibiting and preventing the formation of the wrinkles. Grapeseed oil is containing rich antioxidant and it will be boosting the production of elastin and collagen type I, III, IV to reducing the wrinkles. The grape seed oil is rich in linoleic acid (65-72%), oleic acid (12-23%), palmitic acid (4-11%), stearic acid (8,5-15%). Beside that Grape seed also containing rich with Alpha Tocopherol that have also the major role in maintaining skin barrier function and also gives antioxidant property. Objective: To study the efficacy of grapeseed oil in reducing periorbital wrinkles, to study the efficacy of grapeseed oil in increasing the periorbital skin viscoelasticity, to study the efficacy of grapeseed oil in increasing the periorbital skin barrier function, to evaluate the participants‟ satisfactory scores after using grapeseed oil in this study. Method: 15 healthy volunteers, both male and female Asian Population with the age between 40-60 years old were recruited to participate in double-blind, randomized and split-face study design. They will do the research for 3 months / 12 weeks. And Each of them will be check by Visioscan® VC98 and Cutometer® MP530 in the 0th week, 4th weeks, 8th weeks, and 12th weeks and Tewameter® TM300 in the 0th week and 12th weeks. And in the end of the research or in the 12th weeks every volunteer will fill the form of the satisfaction. Result: Fifteen participants completed the 12-week period study. All measured scores of treated periorbital wrinkle were statistically significant at the level of 0.05 (Paired t-test). The mean of visioscan at under eye and crow’s feet in each visit decreased statistically significant at the level of 0.05 (p<0.001 (Repeated ANOVA). The average cutometer score for the under-eye and crow's feet areas increased significantly in each visit, with a statistical significance level of 0.05. (p<0.001) (repeated ANOVA). The average tewameter score for under-eye and crow’s feet decreased significantly from baseline to the 12th follow-up, with a statistical significance level of 0.05. (p<0.001). The results of comparing the Rao Goldman 5-point visual score on the under eye and crow's feet areas between the grapeseed oil side and placebo side showed that the median score on the grapeseed oil side was significantly higher than the placebo side after 12 weeks. (p<0.001). The results of comparing patients' satisfaction scores for the grapeseed oil side and the placebo side for under-eye and crow's feet showed that the satisfaction scores were significantly higher on the grapeseed oil side compared to the placebo side. (p<0.001). Conclusion: Pure (100%) Grapeseed oil was proven to be safe and effective for the periorbital wrinkle reduction by reducing the wrinkle depth, increasing the skin barrier function and skin elasticity on the periorbital area.

Mae Fah Luang University. Learning Resources and Educational Media Center

Address: CHIANG RAI

Email: library@mfu.ac.th

Name: Sunisa Thaichinda

Role: Advisor

Created: 2023

Modified: 2023-09-20

Issued: 2023-09-20

วิทยานิพนธ์/Thesis

application/pdf

CallNumber: e-Theses

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Dermatology

Grantor: Mae Fah Luang University

©copyrights Mae Fah Luang University

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