Synthetic development for c-h direct acylation of 1-substituted phthalazines

การพัฒนาวิธีสังเคราะห์สำหรับปฏิกิริยาเอซิเลชันของอนุพันธ์ phthalazines

Name: Rungsima Hadsarung

keyword: Phthalazines

; Acyls

; Aldehydes

; Cross–dehydrogenative coupling (CDC)

; Heterocyclic compounds

Abstract: An efficient and simple method for the regiospecific acylation of 1–substituted phthalazines is described in the presence of tert–butyl peroxybenzoate (TBPB) as an oxidant and AlCl3 as an additive in dichloroethane (DCE) at 110 oC. The reaction involves a coupling reaction between 1–substituted phthalazines with aldehydes or alcohols as an acylating agent through an oxidative cross–dehydrogenative coupling (CDC). This strategy provides an alternative method for the acylation of electron–deficient heteroarenes. To illustrate the applicability of the acylated products, the new route for the synthesis of other functional groups for this class of compound was presented by using a simple chemical reaction that allowed further investigation of their potential biological activities.

Thammasat University. Thammasat University Library

Address: BANGKOK

Email: preserv@tu.ac.th

Name: Duangduan Chaiyaveij

Role: advisor

Name: Jutatip Boonsombat

Role: co-advisor

Created: 2022

Modified: 2023-07-11

Issued: 2023-07-11

วิทยานิพนธ์/Thesis

application/pdf

DOI: 10.14457/TU.the.2022.108

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Chemistry

Grantor: Thammasat University

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