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Chotiwid Wiriyachailerd. Preparation of 99mTc-PSMA as a radiopharmaceutical for dingnosis of prostate cancer. (). King Mongkut's University of Technology North Bangkok. Central Library. : , 2023.
Preparation of 99mTc-PSMA as a radiopharmaceutical for dingnosis of prostate cancer
Name: Boon-Uma Jowanaridhi
Organization :
Thailand Institute of Nuclear Technology (Public Organization). Radioisotope Center
Email :
boomuma@tint.or.th
Name: Chotiwid Wiriyachailerd
Organization :
Thailand Institute of Nuclear Technology (Public Organization). Radioisotope Center
LCSH:
Radiopharmaceuticals
LCSH:
Diagnostic imaging
Abstract:
Prostate specific membrane antigen (PSMA) targeting ligands can specifically bind to the active site
of the PSMA enzyme which is highly overexpressed on prostate cancer cells. PSMA ligands labeled with
a variety of radionuclides have been developed and used for diagnosis and therapy of prostate cancer such as
68Ga-PSMA, 18F-PSMA and 17Lu-PSMA. Technetium-99m (9uTc) is the most widely used radioisotope for
diagnosis by single photon emission computed tomography (SPECT) technique. Especially in Thailand,
the access to positron emission tomography (PET) scanning has limitations. Therefore, the development of
a SPECT radiopharmaceutical could be a potential option for diagnostic imaging of prostate cancer. The aim
of this work was to evaluate the radiolabeling conditions of PSMA-I&S with 9"Tc. The radiolabeling was
carried out using various amounts of PSMA-I&S, reducing agent, 99"Tc radioactivity and types of stabilizers.
The results showed that 99mTc-PSMA could be prepared by using 25-50 ug of PSMA-I&S, 22.5-45.0 ug of
stannous chloride dihydrate, 0.12-0.24 mg of disodium tartrate and 30-200 mCi of 99 "Tc. The reaction mixture
was incubated at 100C for 20 min and cooled to room temperature. The radiochemical purity of the product
was more than 90% without purification and the radiopharmaceutical was stable for 6 h.
King Mongkut's University of Technology North Bangkok. Central Library
Address:
BANGKOK
Email:
library@kmutnb.ac.th
Created:
2023
Modified:
2023-06-30
Issued:
2023-06-30
บทความ/Article
application/pdf
BibliograpyCitation :
In Mae Fah Luang University. School of Science. The Pure and Applied Chemistry International Conference 2023 (PACCON 2023) (pp.780-784). Chiang Rai : Mae Fah Luang University
eng
©copyrights King Mongkut's University of Technology North Bangkok
RightsAccess:
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0.017213 วินาที
Boon-Uma Jowanaridhi
| Title | Contributor | Type |
|---|---|---|
| Development of a radiopharmaceutical kit formulation of ethylene dicysteine for renal scan
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Boon-uma Jowanaridhi;Sudkanung Phumkem;Siriwat Thida;Sanguansak Hykunya;Thidarat Petchsoongsakul;Chotiwid Wiriyachailerd | บทความ/Article | |
| Development of a PSMA-11 lyophilized kit for convenient radiolabeling with 68Ga
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Boon-Uma Jowanaridhi;Thidarat Kohud;Kanyapat Lumyong;Suppamat Makjan;Chonticha Phaophang;Sudkanung Phumkem | บทความ/Article | |
| The modified formula of aggregated human albumin in lyophilization form (MAA-Cold kit) by adding human albumin solution
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Thidarat Kohud;Wanpen Rangsawa;Sanguansak Hykunya;Boon-Uma Jowanaridhi;Krittika Somruedee, ;Kanyapat Lumyong;Suppamat Makjan;Chotiwid Wiriyachailerd;Sudkanung Phumkem;Siriwat Thida;Chonticha Phaophang | บทความ/Article | |
| Production and quality control of 177Lu-PSMA for prostate cancer treatment
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| Radiolabeling of DFO-NCS and DFO-NCS siderophore chelator with zirconium-89 radiometal
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Kanyapat Lumyong ;Thidarat Kohud;Suppamat Makjan;Thanete Duangta;Boon-Uma Jowanaridhi ;Chotiwid Wiriyachailerd;Sudkanung Phumkem;Siriwat Thida;Wiranee Sriwiang;Piriya Kaeopookum | บทความ/Article | |
| Validation of analytical methods for the quality control of 99mTc-PSMA-I&S radiopharmaceutical
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Boon-Uma Jowanaridhi;Chotiwid Wiriyachailerd;Siriwat Thida;Krittika Somruedee | บทความ/Article | |
| Effect of batch size and lyophilization condition of dextran-70 radiopharmaceutical kit production for 99m-Technetium preparation
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Chotiwid Wiriyachailerd
| Title | Contributor | Type |
|---|---|---|
| Development of a radiopharmaceutical kit formulation of ethylene dicysteine for renal scan
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Boon-uma Jowanaridhi;Sudkanung Phumkem;Siriwat Thida;Sanguansak Hykunya;Thidarat Petchsoongsakul;Chotiwid Wiriyachailerd | บทความ/Article | |
| The modified formula of aggregated human albumin in lyophilization form (MAA-Cold kit) by adding human albumin solution
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Thidarat Kohud;Wanpen Rangsawa;Sanguansak Hykunya;Boon-Uma Jowanaridhi;Krittika Somruedee, ;Kanyapat Lumyong;Suppamat Makjan;Chotiwid Wiriyachailerd;Sudkanung Phumkem;Siriwat Thida;Chonticha Phaophang | บทความ/Article | |
| Production and quality control of 177Lu-PSMA for prostate cancer treatment
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Suppamat Makjan;Kanyapat Lumyong;Chotiwid Wiriyachailerd;Sudkanung Phumkem;Boon-Uma Jowanaridhi;Thanete Duangta | บทความ/Article | |
| Radiolabeling of DFO-NCS and DFO-NCS siderophore chelator with zirconium-89 radiometal
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Kanyapat Lumyong ;Thidarat Kohud;Suppamat Makjan;Thanete Duangta;Boon-Uma Jowanaridhi ;Chotiwid Wiriyachailerd;Sudkanung Phumkem;Siriwat Thida;Wiranee Sriwiang;Piriya Kaeopookum | บทความ/Article | |
| Validation of analytical methods for the quality control of 99mTc-PSMA-I&S radiopharmaceutical
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Boon-Uma Jowanaridhi;Chotiwid Wiriyachailerd;Siriwat Thida;Krittika Somruedee | บทความ/Article |