แจ้งเอกสารไม่ครบถ้วน, ไม่ตรงกับชื่อเรื่อง หรือมีข้อผิดพลาดเกี่ยวกับเอกสาร ติดต่อที่นี่ ==>
หากไม่มีอีเมลผู้รับให้กรอก thailis-noc@uni.net.th
หากไม่มีอีเมลผู้รับให้กรอก thailis-noc@uni.net.th
Warinthorn Chavasiri. Synthesis and a-glucosidase inhibition of usnic acid enamine 1,2,3-triazole sulfonamide derivatives. (). King Mongkut's University of Technology North Bangkok. Central Library. : , 2023.
Synthesis and a-glucosidase inhibition of usnic acid enamine 1,2,3-triazole sulfonamide derivatives
Name: Pipatpon Raksapon
Organization :
Chulalongkom University, Faculty of Science
Name: Ngo, Thanh The
Organization :
Chulalongkom University, Faculty of Science
Name: Warinthorn Chavasiri
Organization :
Chulalongkom University, Faculty of Science
Email :
warinthom.c@chula.ac.th
keyword:
Usnic acid
LCSH:
Triazoles
LCSH:
Sulfonamides
LCSH:
Enzyme inhibitors
Abstract:
Diabetes mellitus is one of the major metabolic diseases that caused 4.2 million deaths in 2019 with
8.8% of the world population affected. The effective method to manage the symptom was to control blood
sugar level. The glucosidase inhibitor is one group of drugs that help to decrease blood sugar levels by
inhibiting a-glucosidase enzyme which could result in the prevention of starch and disaccharides breakdown
to glucose. Usnic acid and sulfonamide are well-known molecules exhibiting excellent a-glucosidase
inhibition. Nonetheless, the poor solubility of usnic acid in water limits its usage. The connection of both
structures with 1,2,3-triazole bridge might increase the polarity, solubility, and consequently a-glucosidase
inhibitory activity of usnic acid. In this research, N-propargy1 usnic acid enaminone was connected with eight
different sulfonamides via 1,2,3-triazole scaffold using copper(I)-catalyzed azide-alkyne cycloaddition
(CuAAC). The synthesized structures were confirmed by NMR and HRMS. Their in vitro a-glucosidase
inhibition and kinetic study were conducted. The results showed that all synthesized compounds displayed
stronger a-glucosidase inhibition than usnic acid or their parent sulfonamide compounds and are about ten
times stronger than the standard drug (acarbose)
King Mongkut's University of Technology North Bangkok. Central Library
Address:
BANGKOK
Email:
library@kmutnb.ac.th
Created:
2023
Modified:
2023-06-30
Issued:
2023-06-30
บทความ/Article
application/pdf
BibliograpyCitation :
In Mae Fah Luang University. School of Science. The Pure and Applied Chemistry International Conference 2023 (PACCON 2023) (pp.764-769). Chiang Rai : Mae Fah Luang University
eng
©copyrights King Mongkut's University of Technology North Bangkok
RightsAccess:
ใช้เวลา
0.034153 วินาที
Pipatpon Raksapon
| Title | Contributor | Type |
|---|---|---|
| Synthesis and a-glucosidase inhibition of usnic acid enamine 1,2,3-triazole sulfonamide derivatives
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Pipatpon Raksapon;Ngo, Thanh The;Warinthorn Chavasiri | บทความ/Article |
Ngo, Thanh The
| Title | Contributor | Type |
|---|---|---|
| Synthesis and a-glucosidase inhibition of usnic acid enamine 1,2,3-triazole sulfonamide derivatives
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Pipatpon Raksapon;Ngo, Thanh The;Warinthorn Chavasiri | บทความ/Article |
Warinthorn Chavasiri
| Title | Contributor | Type |
|---|---|---|
| Antibacterial activity of anacardic acid derivatives and antioxidant activity of constituents of cashew nut shell liquid
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Kulwadee Tamsampaoloet;Warinthorn Chavasiri | บทความ/Article | |
| Insecticidal constituents from the rhizomes of Stemona curtisii Hook f.
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Olusola Idowu;Warinthorn Chavasiri;Pattara Thiraphibundet | บทความ/Article | |
| Synthesis and a-glucosidase inhibition of usnic acid enamine 1,2,3-triazole sulfonamide derivatives
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Pipatpon Raksapon;Ngo, Thanh The;Warinthorn Chavasiri | บทความ/Article | |
| Structural modification of tanshinone IIA and their a-glucosidase inhibitory activity
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Mutita Kongphet;Hang, Hoa Tai Xuan;Warinthorn Chavasiril | บทความ/Article | |
| Phytic acid as a metal-free catalyst for the synthesis of allylamine derivatives
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Pham, Van Can;Lalita Radtanajiravong;Warinthorn Chavasiril | บทความ/Article |