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Romgase Sakamula. The effect of p-coumaric acid on cerebral ischemia reperfusion injury in mice. Master's Degree(Zoology). Kasetsart University. Office of the University Library. : Kasetsart University, 2017.
The effect of p-coumaric acid on cerebral ischemia reperfusion injury in mice
Name: Romgase Sakamula
Classification :.LCCS: RM666.A555
LCSH:
Antioxidants
LCSH:
Phenolic acids
LCSH:
Neuroprotective agents
LCSH:
Cerebral ischemia
LCSH:
Reperfusion injury
Abstract:
p-Coumaric acid (PC) or 4-hydroxycinnamic acid is a phenolic compound in plants and food stuffs which has antioxidant and anti-inflammatory properties. This study was designed to evaluate the effect of acute and chronic PC pretreatment against cerebral ischemia reperfusion (I/R) injury in mice. Thirty-six male ICR mice were divided into 3 groups of Sham (10% tween80), Control-IR (10% tween80) and PC-IR (PC 100 mg/kg) groups. Animals in acute pretreatment received treatment within 30 minutes before induced I/R and animals in chronic pretreatment daily received treatment for 15 days before induce I/R. I/R induced by bilateral common carotid artery occlusion for 30 minutes following by 45 minutes of reperfusion. After reperfusion, brain was collected for evaluate brain infarction, histological examination of hippocampas and biochemical analysis. The results revealed acute PC pretreatment not significantly decreased brain infarction and percentage of dead cells in hippocampus (p>0.05) and not significantly increased antioxidant enzymes (p>0.05) but chronic PC pretreatment significantly increased catalase and superoxide dismutase (SOD) activities (p<0.05) with significantly decreased MDA, percentage of infarction in whole brain and percentage of dead cell in hippocampus CA1 and DG regions (p<0.05). We suggests chronic pretreatment with PC exert neuroprotective effect via the reduction of brain infarction, lipid peroxidation and modulation of antioxidant properties and may lead to the increase of neuronal strength against I/R injury.
Kasetsart University. Office of the University Library
Address:
Bangkok
Email:
tdckulib@ku.ac.th
Name: Wachiryah Thong-Asa
Role:
Thesis Advisor
Created:
2017
Modified:
2023-06-29
Issued:
2023-06-29
วิทยานิพนธ์/Thesis
application/pdf
URL: https://kasetsart.idm.oclc.org/login?url=https://www.lib.ku.ac.th/KUthesis/2560/romgase-sak-all.pdf
CallNumber:
RM666.A555.R66
eng
DegreeName: Master of Science
Level: Master's Degree
Descipline: Zoology
Grantor: Kasetsart University
©copyrights Kasetsart University
RightsAccess:
ใช้เวลา
0.020147 วินาที
Romgase Sakamula
| Title | Contributor | Type |
|---|---|---|
| The effect of p-coumaric acid on cerebral ischemia reperfusion injury in mice
มหาวิทยาลัยเกษตรศาสตร์ Romgase Sakamula | Wachiryah Thong-Asa | วิทยานิพนธ์/Thesis |
Wachiryah Thong-Asa
| Title | Creator | Type and Date Create |
|---|---|---|
| The effect of p-coumaric acid on cerebral ischemia reperfusion injury in mice
มหาวิทยาลัยเกษตรศาสตร์ Wachiryah Thong-Asa | Romgase Sakamula | วิทยานิพนธ์/Thesis |
| Chronic cerebral hypoperfusion study in ICR mice
มหาวิทยาลัยเกษตรศาสตร์ Wachiryah Thong-Asa | Sirilak Somredngan | วิทยานิพนธ์/Thesis |
| Effect of beta-sitosterol in mice with trimethyltin-induced neurodegeneration
มหาวิทยาลัยเกษตรศาสตร์ Wachiryah Thong-asa | Nurinee Dolrahman. | วิทยานิพนธ์/Thesis |
| The study of p-coumaric acid effects in chronic cerebral hypoperfusion rats
มหาวิทยาลัยเกษตรศาสตร์ Wachiryah Thong-Asa | Natsuda Manyagasa | วิทยานิพนธ์/Thesis |
| Effect of alpha-mangostin and alpha-mangostin-loaded nanostructured lipid carriers on mice models of cerebral ischemia-reperfusion and Parkinsons disease
มหาวิทยาลัยเกษตรศาสตร์ Wachiryah Thong-Asa | Romgase Sakamola | วิทยานิพนธ์/Thesis |