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Watunyoo Buakaew. Bioactivity of Kaffir lime (Citrus hystrix DC.) leaf extract on gingivitis. Doctoral Degree(Biomedical Sciences). NARESUAN UNIVERSITY. NARESUAN UNIVERSITY LIBRARY. : มหาวิทยาลัยนเรศวร, 2566.
Bioactivity of Kaffir lime (Citrus hystrix DC.) leaf extract on gingivitis
Name: Watunyoo Buakaew
ThaSH:
Gingivitis
ThaSH:
Proteomics
ThaSH:
Macrophage
Abstract:
Gingivitis is an inflammatory condition of the gingival tissue. The treatment focuses on both reducing inflammation and removing dental plaque. Chlorhexidine mouthwash is one of the effective choices used as anti-plaque in dental care. However, long-term usage can cause several side effects. This study aimed to develop a safer mouthwash containing Citrus hystrix DC. (kaffir lime, KL) leaf extract, and elucidate the mechanism of action in terms of anti-inflammatory and anti-Candida activities. This study identified the active compound, lupeol that can inhibit the production of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α), the expression of NF-κB- and NLRP3-associated genes (NOS2, NFKB1, IL1B, IL18, NLRP3, and PYCARD) and proteins (COX-2, phospho-IκBα, and NF-κB p65) in macrophages. Additionally, the proteomic analysis revealed proteins that might be involved in the anti-Candida activity under β-citronellol treatment, including oxidative stress response (Sod1p, Gst2p, and Ddr48p), cell wall (Als2p, Rbt1p, and Pga4p), and ATP synthesis-associated proteins (Atp3p, Atp7p, Cox1p, and Cobp). Finally, the mouthwash containing KL leaf extract was developed, and the efficacy was evaluated in 47 participants with mild-to-moderate gingivitis. The reduction of GI, PI scores, and the colony counts of Staphylococcus spp. and Candida spp. were found after 14-day usage. From the results, the mouthwash showed the potential to be used in conjunction with proper oral hygiene to help alleviate gingivitis
NARESUAN UNIVERSITY. NARESUAN UNIVERSITY LIBRARY
Address:
PHITSANULOK
Email:
library@nu.ac.th
Name: Kanchana Usuwanthim
Role:
Assistant Professor
Created:
2566
Modified:
2023-04-25
Issued:
2023-04-25
วิทยานิพนธ์/Thesis
application/pdf
eng
DegreeName: Doctor of Philosophy
Level: Doctoral Degree
Descipline: Biomedical Sciences
Grantor: มหาวิทยาลัยนเรศวร
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ใช้เวลา
-0.974665 วินาที
Watunyoo Buakaew
| Title | Contributor | Type |
|---|---|---|
| Bioactivity of Kaffir lime (Citrus hystrix DC.) leaf extract on gingivitis
มหาวิทยาลัยนเรศวร Watunyoo Buakaew | Kanchana Usuwanthim | วิทยานิพนธ์/Thesis |
Kanchana Usuwanthim
| Title | Creator | Type and Date Create |
|---|---|---|
| ANTICANCER EFFECT OF Citrus hystrix LEAF EXTRACTS ON THE TRIPLE NEGATIVE BREAST CANCER CELL LINE MDA-MB-231
มหาวิทยาลัยนเรศวร Kanchana Usuwanthim | Yathsoeung Ho | วิทยานิพนธ์/Thesis |
| Anti-inflammation and anti-cancer properties of moringa oleifera lam.leaves extract
มหาวิทยาลัยนเรศวร Kanchana Usuwanthim | Thitiya Luetragoon | วิทยานิพนธ์/Thesis |
| Bioactivity of Kaffir lime (Citrus hystrix DC.) leaf extract on gingivitis
มหาวิทยาลัยนเรศวร Kanchana Usuwanthim | Watunyoo Buakaew | วิทยานิพนธ์/Thesis |
| Anticancer effects of moringa oleifera lam.leaf extracts on the human breast cancer cells
มหาวิทยาลัยนเรศวร Kanchana Usuwanthim | Prapakorn Wisitpongpun | วิทยานิพนธ์/Thesis |