Synthesis of analogues of 2-arylaminopyrimidine via the Ullmann coupling

Name: Peera Acharasatian

Organization : Thammasat University. Faculty of Science and Technology

Email : achar001@yahoo.com

Name: Supawadee Popaeng

Name: Thammasat University. Faculty of Science and Technology

LCSH: Nucleosides -- Synthesis

LCSH: Anti-infective agents

Abstract: N-arylation of 2-aminopyrimidine was successfully conducted via the Ullmann coupling reaction. 2-Amino pyrimidine was coupled with four different aryl iodides utilizing CuI / 1,10-phenanthroline as a catalyst to obtain four corresponding 2-arylaminopyrimidine analogues. DMF was exploited as a solvent and K2CO3 was applied as a base. Each reaction mixture was heated at 150 °C for 6–24 h. Percentage yields varied greatly with the substituent group of the aryl iodide. Electron-rich aryl iodides usually took longer reaction time and gave lower percentage yields. Ethyl acetate was found to be more effective than dichloromethane as an extraction solvent. Products were purified by column chromatography and characterized by mp, 1H-NMR, and MS

King Mongkut's University of Technology North Bangkok. Central Library

Address: BANGKOK

Email: library@kmutnb.ac.th

Created: 2016

Modified: 2023-01-13

Issued: 2023-01-13

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BibliograpyCitation : In Chemical Society of Thailand under the Patronage of Professor Dr. HRH Princess Chulabhorn and Chulalongkorn University Faculty of science. Pure and Applied Chemistry International Conference (PACCON 2016) (pp.1566-1569). Bangkok : Chemical Society of Thailand under the Patronage of Professor Dr. HRH Princess Chulabhorn

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