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Kornkanok Buasiri. Antituberculosis alkaloids from the roots of Zanthoxylum rhetsa. (). King Mongkut's University of Technology North Bangkok. Central Library. : , 2016.
Antituberculosis alkaloids from the roots of Zanthoxylum rhetsa
Name: Pichit Sudta
Organization :
Phetchaburi Rajabhat University. Faculty of Science and Technology
Email :
pichitsud@gmail.com
Name: Kornkanok Buasiri
Organization :
Phetchaburi Rajabhat University. Faculty of Science and Technology
keyword:
Indian prickly ash
LCSH:
Tuberculosis
LCSH:
Plant extracts
-- Therapeutic use
Abstract:
The ethyl acetate extract from the roots of Zanthoxylum rhetsa was investigated.
Seven known alkaloids, dihydroavicine (1), dihydronitidine (2), N-methylflindersine (3), 8-
acetonyldihydroavicine (4), paraensidimerine A (5), 8-acetonyldihydronitidine (6), and
skimmianine (7) were isolated. Among them, alkaloids 3-5 were obtained for the first time
from this plant. Compounds 3 and 6 exhibited the highest anti-TB activity with MIC value of
12.5 μg/mL. The SAR study showed that the free pyran moiety of 3 and the presence of the
methoxyl groups at C-2 and C-3 and acetonyl moiety at C-8 of 6 are essential for anti-TB
activity. To verify the potential of the acetonyl group of compound 6, 8-(2-
hydroxypropyl)dihydronitidine (8) was synthesized and evaluated for its anti-TB activity.
The decrease in activity of 8 indicated that acetonyl moiety is crucial for anti-TB potency
King Mongkut's University of Technology North Bangkok. Central Library
Address:
BANGKOK
Email:
library@kmutnb.ac.th
Created:
2016
Modified:
2023-01-03
Issued:
2023-01-03
บทความ/Article
application/pdf
BibliograpyCitation :
In Chemical Society of Thailand under the Patronage of Professor Dr. HRH Princess Chulabhorn and Chulalongkorn University Faculty of science. Pure and Applied Chemistry International Conference (PACCON 2016) (pp.1007-1013). Bangkok : Chemical Society of Thailand under the Patronage of Professor Dr. HRH Princess Chulabhorn
eng
©copyrights King Mongkut's University of Technology North Bangkok
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Pichit Sudta
| Title | Contributor | Type |
|---|---|---|
| Antituberculosis alkaloids from the roots of Zanthoxylum rhetsa
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Pichit Sudta;Kornkanok Buasiri | บทความ/Article |
Kornkanok Buasiri
| Title | Contributor | Type |
|---|---|---|
| Antituberculosis alkaloids from the roots of Zanthoxylum rhetsa
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Pichit Sudta;Kornkanok Buasiri | บทความ/Article |