Development of gold nanorods stabilized with drug-conjugated polymer for synergistic cancer therapy

Name: Phim-on Khunsuk

Organization : Chulalongkorn University. Faculty of Science

Name: Voravee P. Hoven

Organization : Chulalongkorn University. Faculty of Science

Email : vipavee.p@chula.ac.th

keyword: Gold nanorods

LCSH: Drug delivery systems

LCSH: Cancer -- Chemotherapy

ThaSH: Synergetics

Abstract: Taking advantages of gold nanorod (AuNRs) being capable of providing synergistic efficiency for cancer treatment via the combination of photothermal therapy and chemotherapy and their tunable properties as a function of stabilizer, this work aims to develop anticancer drug delivery system based on AuNRs stabilized with poly[(methacrylic acid)-ran-(methacryloyloxyethyl phosphorylcholine)] (PMAMPC). PMAMPC was synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization. Some carboxyl groups in PMAMPC were modified with cysteamine to introduce more thiol groups to increase active binding sites for each PMAMPC chains onto AuNRs surface. Remaining carboxyl groups were covalently bonded with hydrazine using EDC/NHS activation. Then, doxorubicin (DOX), an anticancer drug was conjugated to PMAMPC by acid-labile hydrazone linkage which should be rapidly destroyed under acidic environment in lysosomes. PMAMPC-DOX was coated on AuNRs surface via Au-S bonds. The resulting PMAMPC-DOX-AuNRs showed good colloidal stability and uniform size. Photothermal studies verified that the particles can convert the absorbed light into heat (>70 °C) when irradiated with NIR laser at 808 nm. In vitro drug release studies demonstrated that DOX release can be significantly accelerated at pH 5.0. These results suggested that PMAMPCDOX- AuNRs could potentially be applied in pH-triggered drug delivery for synergistic cancer therapy.

King Mongkut's University of Technology North Bangkok. Central Library

Address: BANGKOK

Email: library@kmutnb.ac.th

Created: 2016

Modified: 2022-12-29

Issued: 2022-12-29

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BibliograpyCitation : In Chemical Society of Thailand under the Patronage of Professor Dr. HRH Princess Chulabhorn and Chulalongkorn University Faculty of science. Pure and Applied Chemistry International Conference (PACCON 2016) (pp.962-967). Bangkok : Chemical Society of Thailand under the Patronage of Professor Dr. HRH Princess Chulabhorn

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