Solid-liquid lipid mixtures study by coarse-grained molecular dynamics simulations

การศึกษาระบบผสมของไขมันและน้ำมันโดยใช้การจำลองพลวัตเชิงโมเลกุลแบบคอร์สเกรนด์

Name: Yenruedee Thiangjit

keyword: Coarse-grained molecular dynamics

; Solid-liquid lipid mixtures

; Stearic acid

; Cetyl palmitate

; Oleic acid

; Isopropyl palmitate

Abstract: Solid Lipid nanoparticle is a very important carrier in the drug delivery system. It was developed in early 1990s as an alternative to other traditional colloidal carriers like liposomes, polymeric nanoparticles and emulsions as it has an increased stability. It is formulated based on the mixture of lipids. However, the mixture of lipids must be carefully chosen to ensure the stability and the good mixing between different lipids. To understand the stability and the structure of lipid nanoparticles, binary mixtures of solid-liquid lipids will be modeled using coarse-grained molecular dynamics simulations to investigate their phase separation behaviors as a function of lipid types and solid-liquid lipid ratios. We will use stearic acid (STA) and cetyl palmitate (CTP) as solid lipids. Oleic acid (OLA) and isopropyl palmitate (IPP) will be selected as liquid lipids. Aggregation of binary lipid mixtures will be studied by varying ratios of solid lipid and liquid lipid starting from the lipid molecules dispersed randomly in water. The structural properties of the lipid aggregates such as the radial distribution function and the density profile, will be calculated. The analysis of simulation data should provide a guideline for selecting a pair of solid-liquid lipids for a stable lipid nanoparticles formulation

Thammasat University. Thammasat University Library

Address: BANGKOK

Email: preserv@tu.ac.th

Name: Yuthana Tantirungrotechai

Role: advisor

Created: 2020

Modified: 2022-12-29

Issued: 2022-12-29

วิทยานิพนธ์/Thesis

application/pdf

DOI: 10.14457/TU.the.2020.516

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Chemistry

Grantor: Thammasat University

©copyrights Thammasat University

ลำดับที่.	ชื่อแฟ้มข้อมูล	ขนาดแฟ้มข้อมูล	จำนวนเข้าถึง	วัน-เวลาเข้าถึงล่าสุด
1	9878yenruedee.pdf	3.48 MB

ใช้เวลา

0.030371 วินาที