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Paisan Kittisupakorn. Heat transfer modeling of deferasirox purification in a batch process. (). King Mongkut's University of Technology North Bangkok. Central Library. : , 2022.
Heat transfer modeling of deferasirox purification in a batch process
Name: Naruporn Savetvivat
Organization :
Chulalongkorn University. Faculty of Engineering
Email :
pear.naruporn@gmail.com
Organization :
Naresuan University. Faculty of Engineering
Name: Paisan Kittisupakorn
Organization :
Chulalongkorn University. Faculty of Engineering
Email :
paisan.k@chula.ac.th
LCSH:
Deferasirox
-- Purification
Abstract:
Deferasirox (DFX), a chelating agent of iron (Fe+3), is an active pharmaceutical ingredient (API) normally used for thalassemia patients who have an iron overload from a blood transfusion. It is prepared by the reaction of benzoxazinone and 4-Hydrazinobenzoicacid in ethanol in a batch process. However, impurity deferasirox in a form of 4-Hydrazinobenzoicacid or hydrazine impurity, a carcinogen, which affects the safety of pharmaceutical products definite always takes place at the end of a DFX preparation reaction. The hydrazine impurity can be removed by adding sodium hydroxide of 303K and heating to 328K to produce a highly pure deferasirox salt, substantially free from hydrazine impurity and pharmaceutically acceptable salt. To achieve a set point condition, a deferasirox purification process of a 1-liter scale-down size has been studied to represent that of a 10 liters pilot scale using a reaction calorimeter (Mettler Toledo, RC1). Experimental study has been carried out to gather information of the scale-down process. With these experimental data, its model has been developed and used to formulate a controller to control the reactor temperature. The sodium hydroxide addition rate in a deferasirox purification process has been studied with temperature profile of the process. The heat transfer coefficient of the reaction calorimeter and the pilot-scale reactor can be determined by heat balance equation and using the Python and Excel programs. Finally, the temperature profiles from the model have been compared with these of the experimental data to evaluate the accuracy and applicability of the heat transfer model.
King Mongkut's University of Technology North Bangkok. Central Library
Address:
BANGKOK
Email:
library@kmutnb.ac.th
Created:
2022
Modified:
2022-12-14
Issued:
2022-12-14
บทความ/Article
application/pdf
BibliograpyCitation :
In Naresuan University. The 31st Thai Institute of Chemical Engineering and Applied Chemistry Conference (TiCHE 2022) (pp.441-452). Phitsanulok : Naresuan University
eng
©copyrights King Mongkut's University of Technology North Bangkok
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0.033613 วินาที
Naruporn Savetvivat
| Title | Contributor | Type |
|---|---|---|
| Heat transfer modeling of deferasirox purification in a batch process
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Naruporn Savetvivat;Weerawun Weerachaipichasgul;Paisan Kittisupakorn | บทความ/Article |
Weerawun Weerachaipichasgul
| Title | Contributor | Type |
|---|---|---|
| Heat transfer modeling of deferasirox purification in a batch process
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Naruporn Savetvivat;Weerawun Weerachaipichasgul;Paisan Kittisupakorn | บทความ/Article |
Paisan Kittisupakorn
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| Heat transfer modeling of deferasirox purification in a batch process
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