Development of topical film forming spray containing garcinia cowa leaf extract nanoemulsion for pharmaceutical and cosmeceutical products

Name: Kanyawadee Bureekaew

keyword: Garcinia cowa Leaf Extract

MeSH: Garcinia Cowa -- 52681

Classification :.DDC: e-Theses

; Nanoemulsion, Topical Film Forming Spray, Pharmaceutical and Cosmeceutical Products

MeSH: Emulsions -- 289905

MeSH: Cosmetics -- Pharmaceutical chemistry -- 289906

MeSH: Pharmaceutical chemistry -- 289907

LCSH: Garcinia Cowa -- 52681

LCSH: Emulsions -- 289905

LCSH: Cosmetics -- Pharmaceutical chemistry -- 289906

LCSH: Pharmaceutical chemistry -- 289907

Abstract: The aim of this study was to fabricate and characterize topical film forming spray containing Garcinia cowa leaf extract (GC) nanoemulsion for use as pharmaceutical and cosmeceutical products. The GC nanoemulsion was first prepared by ultrasonic method. Properties of the GC nanoemulsion, including morphology, particle size, polydispersity index (PDI), zeta potential, thermal properties, and stability were investigated. In addition, encapsulation efficiency (%EE), release study, antibacterial activity, antioxidant activity, anti-inflammatory activity, and indirect cytotoxicity were investigated. The results showed that the particle size of GC nanoemulsion ranged between 66 and 71 nm, PDI ranged between 0.17 and 0.28, and zeta potential ranged between -17 and -10 mV. The cumulative released amount of GC nanoemulsion ranged between 14 and 31%. In addition, the GC nanoemulsion exhibited the inhibition against both gram-negative and gram-positive bacteria and showed good antioxidant activity. The GC nanoemulsion was also non-toxic to NCTC clone 929 cells. Thus, the GC nanoemulsion could incorporate into the topical film forming spray for use as pharmaceutical and cosmeceutical products. The topical film forming spray was prepared using Eudragit E100 (EuE100) as polymeric system, dibutyl phthalate (DBP) as plasticizer, GC nanoemulsion as drug, polyvinyl pyrrolidone (PVP) as binder and enhancer, and ethanol as solvent. From the results, the increase of EuE100 concentration caused the viscosity to increase but the spray pattern to decrease. All formulations (S1-S6) showed the evaporation time in the range of 3.27-7.10 min and the contact angle was low, in the range of 19.05-30.04°. Finally, the topical film forming film containing GC nanoemulsion showed good antibacterial, anti-inflammatory, and non-toxic to the cells. Thus, this topical film forming spray containing GC nanoemulsion have the potential for use as pharmaceutical and cosmeceutical products.

Mae Fah Luang University. Learning Resources and Educational Media Center

Address: CHIANG RAI

Email: library@mfu.ac.th

Name: Orawan Suwantong

Role: Advisor

Created: 2021

Modified: 2022-08-08

Issued: 2022-08-08

วิทยานิพนธ์/Thesis

application/pdf

CallNumber: e-Theses

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Applied Chemistry

Grantor: Mae Fah Luang University

©copyrights Mae Fah Luang University

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