Effect of synbiotic supplement on gut brain axis in night shift workers with excessive sleepiness

Name: Phutharaksa Phumcharoen

keyword: Synbiotic

MeSH: Mental Disorders -- complications -- Research -- 275548

Classification :.DDC: WM140

; Night-shift workers

MeSH: Sleep Disorders -- complications -- Shift worker -- 275549

MeSH: Shift worker -- sleepiness -- Research -- 275550

LCSH: Mental Disorders -- complications -- Research -- 275548

LCSH: Sleep Disorders -- complications -- Shift worker -- 275549

LCSH: Shift worker -- sleepiness -- Research -- 275550

Abstract: Background: Many shift workers have a misaligned biological clock especially night-shift workers. Changes in circadian timing also contribute to excessive sleepiness. Sleep deprivation are associated with gut dysbiosis, and circadian disruption alters the gut microbiota. In addition, circadian misalignment has a negative impact on health, including brain functions. Furthermore, there may be a link between the gut and the brain. Probiotic supplementation has been found to improve subjective sleep quality, which is linked to gut microbiota balance, according to a previous study. Aims and Objective: To study the possible result of synbiotic supplement affect on gut-brain axis in night-shift workers with excessive sleepiness through alterations of gut related parameters, changing of Epworth Sleepiness scale and Go/No go task. Materials and Methods: This was a single-group experiment using pre-test and post-test research designs. Eleven night-shift workers with excessive sleepiness, aged from 25 to 60 years old, participated in the study. Synbiotic including probiotics from 7 species and prebiotics from 3 types are given to participants once a day before bedtime during eight weeks. Results : After 8 weeks of taking a synbiotic supplement, there were significant improvements of LPS level (p= 0.029), IgA level(p= 0.008), Lactulose absorption (p= 0.010) and lactulose/mannitol ratio (p= 0.003). Furthurmore, there was a significant increase of 5-HIAA (p= 0.018) and decrease of QA/5-HIAA ratio (p= 0.027). In neurobehavioral result, this study was a significantly improved that the ESS score (p= 0.003). Even though there was a decrease in the percentage of correct responses after 8 weeks of synbiotic supplementation in night-shift workers with excessive sleepiness, it was not statistically significant. Other aspects of the go/no go task, such as the percentage of false alarms and omission errors, as well as reaction time, increased slightly but not significantly. Conclusion: According to the findings of this study, taking a synbiotic supplement improves intestinal permeability, decreases systemic inflammation but does not improve neurobehavioral brain functions. Further research is being done using event-related potential (ERP) to see how synbiotic supplementation affects cognitive brain functions and how they are linked to gut parameters.

Mae Fah Luang University. Learning Resources and Educational Media Center

Address: CHIANG RAI

Email: library@mfu.ac.th

Name: Phakkharawat Sittiprapaporn

Role: Advisor

Created: 2021

Modified: 2021-12-17

Issued: 2021-12-17

วิทยานิพนธ์/Thesis

application/pdf

CallNumber: WM140 P577e 2020

eng

DegreeName: Doctor of Philosophy

Level: Doctoral Degree

Descipline: Anti-Aging and Regenerative Medicine

Grantor: Mae Fah Luang University

©copyrights Mae Fah Luang University

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