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Lwin San Mei Aung. A comparative syudy of the efficacy between 5% morinda citrifolia fruit extract crean and placebo cream for treatment of melasma. Master's Degree(Dermatology). Mae Fah Luang University. Learning Resources and Educational Media Center. : Mae Fah Luang University, 2021.
A comparative syudy of the efficacy between 5% morinda citrifolia fruit extract crean and placebo cream for treatment of melasma
Comparative syudy of the efficacy between 5% morinda citrifolia fruit extract crean and placebo cream for treatment of melasma
Name: Lwin San Mei Aung
keyword:
Melasma
Classification :.DDC: WR140
Abstract:
Background: Melasma is one of the most commonly acquired hyperpigmentations that mainly affects the face. Later, natural plant extracts gain popularity for treatment of melasma due to its lesser side effects. Therefore, the researcher reviews on Morinda citrifolia (Noni) fruit extract which has anti-tyrosinase activity as a potential alternative.
Objective: To study the efficacy of 5% Morinda citrifolia fruit extract cream for the treatment of melasma.
Method: 16 volunteers were selected according to inclusion criteria. 5% Morinda citrifolia fruit extract cream and placebo cream were applied comparatively in split face design for 8 weeks, two times per day. Sunscreens and mild soaps were also provided. The researcher took a photograph of each patient using VISIA®. Mexameter® MX18 measurement and MASI score were evaluated by the dermatologist at baseline, 4th week, 8th week and 12th week respectively. Adverse effects and satisfactory score of the volunteers were observed and evaluated by three dermatologists and recorded throughout the study.
Result: The mean of MASI score in 5% Morinda citrifolia fruit extract cream showed significant reduction from baseline 7.09±1.50 to 6.80±1.41, 6.26±1.31 and 5.67±1.07 at 4th week, 8th week and 12th week respectively with P-value <0.001 meanwhile mean of MASI score in placebo cream increased from baseline 7.26±1.79 to 7.41±1.79, 7.60±1.69 and 7.69±1.45 at 4th week, 8th week and 12th week respectively. The mean melanin index of 5% Morinda citrifolia fruit extract cream was significantly reduced from baseline 219.77±57.31 to 196.33±53.59, 181.32±48.88 and 166.36±43.65 at 4th week, 8th week and 12th week respectively with P-value <0.001. But the mean melanin index of placebo cream increased from baseline 223.70±65.31 to 225.41±65.38, 228.14±67.06 and 229.10±65.33 at 4th week, 8th week and 12th week respectively. No adverse effects were noted throughout the study. No serious adverse effects were noted throughout the study.
Conclusion: This study statistically demonstrated that 5% Morinda citrifolia fruit extract cream can also be used as an alternative treatment for melasma
Mae Fah Luang University. Learning Resources and Educational Media Center
Address:
CHIANG RAI
Email:
library@mfu.ac.th
Role:
Advisor
Created:
2021
Modified:
2021-12-15
Issued:
2021-12-15
วิทยานิพนธ์/Thesis
application/pdf
CallNumber:
WR140 L979c 2020
eng
DegreeName: Master of Science
Level: Master's Degree
Descipline: Dermatology
Grantor: Mae Fah Luang University
©copyrights Mae Fah Luang University
RightsAccess:
ใช้เวลา
0.035811 วินาที
Lwin San Mei Aung
| Title | Contributor | Type |
|---|---|---|
| A comparative syudy of the efficacy between 5% morinda citrifolia fruit extract crean and placebo cream for treatment of melasma
มหาวิทยาลัยแม่ฟ้าหลวง Lwin San Mei Aung | Thamthiwat Nararatwanchai | วิทยานิพนธ์/Thesis |
Thamthiwat Nararatwanchai