Efficacy and safety of calcipotriol ointment vs desoximetasone ointment in the treatment of chronic hand eczema : a double-blinded, randomized right-left comparison trial

Name: Ratchasin Pongprasert

keyword: Chronic hand eczema

LCSH: Eczema -- Treatment

; Calcipotriol

; Topical vitamin D analogues

; Desoximetasone

; Treatment

Abstract: Chronic hand eczema is a common dermatologic condition which frequently relapses and has poor response to conventional therapies. Topical potent corticosteroids is the treatment of choice for chronic hand eczema (CHE). However, it prone to induce considerable side effects after long-term usage. Topical vitamin D analogues has been approved in the treatment of psoriasis and was reported to achieve beneficial effect in many other inflammatory diseases. The aim of this research is to assess the efficacy and safety of calcipotriol ointment comparing to desoximetasone ointment in the treatment of CHE. Patients who reach the inclusion criteria were recruited and both of their hands were randomized either to be treated with calcipotriol or desoximetasone ointment twice daily for 8 weeks. Four weeks after discontinuation of the treatment, recurrence was assessed. The efficacy was evaluated by HECSI scores and patient self’s assessment at baseline, the 2nd, 6th, 8th and 12th week and digital photographs were taking at baseline, 8th week and 12th week. Any adverse reaction was recorded during the experiment. The result revealed a statistically improvement of mean HECSI compared to the baseline sine the 2nd week of treatment (p < 0.001) and reached 75% reduction by the end of treatment period with no significant difference between the two regimens (p > 0.05). Almost all subjects reported more than 50% improvement at the end of the study. The most common side effect for calcipotriol was mild scaling and mild dryness for desoximetasone. In conclusion calcipotriol is as effective as desoximetasone and safe for chronic hand eczema which may further considered as an alternative treatment

Thammasat University. Thammasat University Library

Address: BANGKOK

Email: preserv@tu.ac.th

Name: Premjit Juntongjin

Role: advisor

Created: 2016

Modified: 2021-05-31

Issued: 2021-05-31

วิทยานิพนธ์/Thesis

application/pdf

DOI: 10.14457/TU.the.2016.545

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Dermatology

Grantor: Thammasat University

©copyrights Thammasat University

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