Abstract:
Background: To be effective in protecting against the harmful effects of ultraviolet radiation (UVR), many photoprotective strategies have been used. Inadequate physical protection, amount of topical application and allergic reactions to topical agents are limitations associate with current photoprotective strategies. Systemic agents are an emerging alternative, providing promising protection against solar radiation. Objective: Our primary objective is to systematically review photoprotective outcomes of oral plants and animals derived agents from available clinical studies by using evidence-based method and our secondary objective is to summarize the possible mechanisms of individual plants and animals derived agents as oral photoprotection from available clinical studies. Methods: PubMed EBSCO and Cochrane databases were systematically searched for randomized controlled trials (RCTs), evaluating outcomes of the systemic natural product-based agents. Results: Total 22 clinical trials with 800 participants were identified and organized into two categories. Plant-derived agents include golden serpent fern, green tea, cocoa bean, tomato, beta-carotene and vitamin E, while animal-derived products consist of nicotinamide, and omega-3 polyunsaturated fatty acids. Conclusion: Systemic plant and animal-derived photoprotective agents may be a promising alternative in addition to conventional photoprotection. To better determine its effectiveness and roles, further extensive clinical trials are required
Thammasat University. Thammasat University Library