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Suriyawut Kulatee. Theoretical investigation of enantioselective ligand-host binding interactions. Master's Degree(Engineering and Technology). Thammasat University. Thammasat University Library. : Thammasat University, 2017.
Theoretical investigation of enantioselective ligand-host binding interactions
Name: Suriyawut Kulatee
keyword:
Enantioselectivity
Abstract:
Enantiomerically pure compounds are highly demanded by the pharmaceutical, agrochemical, food additives, fragrances, and catalysts industries. Their separations require appropriate technique and the problem arise with the selection of appropriate systems of chiral selector-selectand combinations. The identification of suitable selectors for separating enantiomers requires considerable experimentation which is highly demanding with respect to time, material and labor. With the help of molecular modeling, the researchers can visualize three-dimensional structures of any chemical compounds in any kind of simulated environment, allowing them to study their physical and chemical properties. In this study, two chiral systems are studied ; the chemical system consisting of beta-cyclodextrin (chiral host) and nicotine enantiomers (chiral guests), and the biological system consisting of wild-type and mutant pfDHFR (chiral hosts) and cycloguanil derivatives enantiomers (chiral ligands). The research aims to study the effect of stereochemistry in chiral hosts on the chiral guests and to predict their enantioselectivity as the potential chiral selector. The findings indicate the potential use of both beta-cyclodextrin and pfDHFR as the chiral selectors in separating nicotine and cycloguanil derivatives enantiomers, respectively.
Thammasat University. Thammasat University Library
Address:
BANGKOK
Email:
preserv@tu.ac.th
Name: Luckhana Lawtrakul
Role:
advisor
Created:
2017
Modified:
2021-05-13
Issued:
2021-05-13
วิทยานิพนธ์/Thesis
application/pdf
eng
DegreeName: Master of Science
Level: Master's Degree
Descipline: Engineering and Technology
Grantor: Thammasat University
©copyrights Thammasat University
RightsAccess:
ใช้เวลา
-0.960693 วินาที
Suriyawut Kulatee
| Title | Contributor | Type |
|---|---|---|
| Preservation of nicotine by nanoencapsulation technique using β-cyclodextrin
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Nathasak Sinlikhitkul;Harid Pataveepaisit;Waritsara Noodang;Arayaporn Krissawong;Suriyawut Kulatee;Anotai Suksangpanomrung;Luckhana Lawtrakul;Pisanu Toochinda | บทความ/Article | |
| Theoretical investigation of enantioselective ligand-host binding interactions
มหาวิทยาลัยธรรมศาสตร์ Suriyawut Kulatee | Luckhana Lawtrakul | วิทยานิพนธ์/Thesis |
Luckhana Lawtrakul