Development of encapsulated antimicrobial additives to extend bioactivity

Name: Kanita Boonruang

keyword: Copper

; Sol-Gel process

; Antimicrobial

; Paint

; Cu/SiO2 microspheres

Abstract: The development of silica microspheres that contain immobilized copper has led to the application of antibacterial or antifungal paint additive that is effective, yet safe to human beings. However, the fast release of copper when the microspheres suspended in water-based solvent remains problematic as it reduces the useful lifetime of their applications, such as paint additives. A slow and controlled release is often preferred to achieve efficient and prolonged antimicrobial effect. In this study, the release of copper from acrylic-coating can be controlled by varying the silica to copper ratio and by forming the microspheres with complex pore properties. The goal of the research was to develop antimicrobial additives for paint. The additives were synthesis by modified silica-copper microparticles with 3-glycidyloxypropyltrimethoxysilane (GLYMO) and 3-Aminopropyl)triethoxysilane (APTES). This work involvs the incorporation of copper (II) in form of copper acetate (Cu(CO2CH3)2) to silica microparticles by using tetraethoxysilane (TEOS) as a precursor. Copper loading capacity and copper adherence on silica surface were enhanced by addition of GLYMO and APTES. The objective is to produce Cu/SiO2 microspheres to be mixed in antimicrobial paint that can inhibit growth of Escherichia coli (E.coli) and Penicillium funiculosum (P. funiculosum). The effects in the addition of GLYMO/APTES to TEOS solution were studied. The sol-gel formation with acid catalysts was used in combination with a spray dryer to obtain Cu/SiO2 microspheres. The morphology of Cu/SiO2 microspheres was observed using Field Emissive Scanning Electron Microscope (FE-SEM) to determine the particle size and particles size distributions. Energy-dispersive spectrometry (EDS) and X-ray Fluorescence (XRF) used an elemental analysis method to identify and quantify all compounds. The specific functional groups of modified surfaces was confirmed by Fourier Transform Infrared Spectroscopy (FTIR). Thermogravimetric Analysis (TGA) was used to measure percent weight loss to determine the organosilane content in Cu/SiO2 microspheres. ImageJ program was used to determine the area of microorganism growth on the paints surface, which was used to calculate the inhibition rate. The higher proportion of additives present in paints, the higher the antimicrobial activities

Thammasat University. Thammasat University Library

Address: BANGKOK

Email: preserv@tu.ac.th

Name: Wanwipa Siriwatwechakul

Role: advisor

Created: 2017

Modified: 2021-04-20

Issued: 2021-04-20

วิทยานิพนธ์/Thesis

application/pdf

DOI: 10.14457/TU.the.2017.1016

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Engineering and Technology

Grantor: Thammasat University

©copyrights Thammasat University

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