A Comparative study of the efficacy between 5% citrus grandis extract cream and 2% hydroquinone cream for the treatment of melasma in thai people

Name: Aye Su Myat Thaung

Organization : Mae Fah Luang University

keyword: Citrus Grandis

ThaSH: Dermatology -- treatment

; Hydroquinone

ThaSH: Skin Diseases -- therapy

; Melasma

ThaSH: Dermatology -- methods

Abstract: Background: Melasma is a common, acquired and therapeutically challenging hyperpigmentary disorder that has delirious impact on the patient’s quality of life. Pathogenesis of melasma is complex and the contributing factors that are often implicated in its etiopathogenesis are exposure to intense ultraviolet radiation, genetic predisposition and hormonal influences. Therapeutic interventions include multimodality approach incorporating photo protection agents, topical and oral medications, and peeling and laser treatments. As a potential alternative for the treatment of melasma, this research reviews on liposomal-encapsulated citroflavonoids extracted from citrus fruits which is proved to be safe and effective in both in-vivo and in-vitro studies due to its anti-tyrosinase activity and skin whitening properties. Aim: The aim of this study is to compare the efficacy between 5% Citrus grandis fruit extract cream and 2% hydroquinone cream for the treatment of melasmaMaterials and methods: Sixteen healthy volunteers with melasma depending on the inclusion and exclusion criteria were enrolled in a double-blinded, randomized split face controlled clinical trial. This study was conducted in Mae Fah Luang University Hospital, Bangkok, Thailand. 5% Citrus grandis fruit extract cream and 2% hydroquinone cream were randomly applied in designated sides of the face twice daily for twelve weeks. Melasma Area and Severity Index (MASI) and Mean Melanin Index by using Mexameter® MX18 were assessed together with the VISIAⓇ complexion analysis system at the time of their first attendance, 4th week, 8th week and 12th week respectively. Adverse effects and satisfaction scores were observed and recorded at each visit throughout the clinical trial. Results: All sixteen volunteers completed the twelve-week period study. The mean MASI scores of both 5% Citrus grandis fruit extract cream and 2% hydroquinone cream showed statistical significant reduction with a result of 0.05 (p<0.001). The mean Mexameter score was significantly reduced in both treatment groups with p value of <0.001 at each visits. The mean percentage change of MASI score and Mexameter at 4th week, 8th week and 12th week between the two groups had no statistical significant differences. No adverse effects from both groups were noted throughout the whole period of the study. Conclusion: The study has proved that 5% Citrus grandis fruit extract cream have same efficacy as 2% hydroquinone cream which is the standard treatment in melasma. On the basis of these results, 5% Citrus grandis can be used as an effective, safe and alternative therapeutic agent in the treatment of melama.

Mae Fah Luang University. Learning Resources and Educational Media Center

Address: CHIANG RAI

Email: library@mfu.ac.th

Name: Rassapoom Sumaetheiwit

Role: Advisor

Created: 2021

Modified: 2564-03-08

Issued: 2021-03-08

วิทยานิพนธ์/Thesis

application/pdf

CallNumber: Thesis WR140 A976c 2019

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Dermatology

Grantor: Mae Fah Luang University

©copyrights Mae Fah Luang University

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