Hydrogels of sodium carboxymethyl cellulose/polyacrylamide ipns for controlled delivery : preparation and characterization

Name: Netchanok Phumithat

keyword: Interpenetrating Polymer Networks

; Polyacrylamide

; Sodium Carboxymethyl Cellulose

; Mangiferin

Abstract: Interpenetrating polymer network (IPN) hydrogels of polyacrylamide (PAAm) and sodium carboxymethyl cellulose (NaCMC) were prepared by free radical polymerization and crosslinking. Potassium persulfate, citric acid and N,N’- methylenebisacrylamide (MBAAm) were used as an initiator for acrylamide monomer, and crosslinking agents for NaCMC and PAAm, respectively. The non-porous and porous PAAm/NaCMC IPN hydrogels were prepared and characterized for controlled release application. The properties of hydrogels were studied in terms of gel content, swelling, water-holding capacity, thermal stability, morphology and porosity. The results from gel fraction and Attenuated total reflection-Fourier transform infrared (ATR-FTIR) analysis suggested that the hydrogels were successfully prepared and crosslinked. The swelling was studied in distilled water and buffer solutions at pH 5.5 and pH 10.0. The results showed that the swelling ratio of hydrogels increased with increasing NaCMC composition and pH value. On the other hand, the swelling profiles of porous hydrogels were faster than those of the dense samples at the same compositions. To evaluate the possibility of hydrogels for wound dressing application, mangiferin was used as a model drug and loaded in the IPNs. The release behavior of hydrogels were studied in both pH 5.5 (pH of normal skin) and 10.0 (pH of wound infection) buffer solutions. It was found that all samples showed higher amount of released mangiferin in pH 10.0 than those in pH 5.5 buffer solution. Moreover, the NaCMC composition and porosity played an important role in controlled release of mangiferin from hydrogels. According to the kinetic models, the release of mangiferin was controlled by diffusion mechanism with swelling of the matrix. These findings v indicated that the hydrogels could be a potential alternative for wound dressing material. To develop the pH-sensitive character of PAAm/NaCMC IPNs for oral drug delivery, the pH-sensitive hydrogels were obtained after alkaline hydrolysis. The conversion of amide (-CONH2) to carboxylate groups (-COO- ) after hydrolysis was confirmed by ATR-FTIR spectroscopy. Swelling ability of the hydrolyzed hydrogels was investigated as a function of time and pH in different buffer solutions similar to that of simulated gastrointestinal fluid. It was found that the swelling ratio in pH 7.4 buffer solution was considerably higher than in pH 1.2 buffer solution. This change in swelling behavior was attributed to the presence of carboxylate anion groups in hydrogels that either protonated or deprotonated in response to the pH media. The release profiles showed that low amount of mangiferin was release in pH 1.2 buffer solution. On the other hand, the release rate increased rapidly in pH 7.4 environment because the ionization of carboxylate groups caused the repulsion between the polymer molecules and significant swelling of hydrogels. As a result, diffusion of mangiferin out of the hydrogels was facilitated. According to the kinetic model, the release of mangiferin from hydrolyzed hydrogels was controlled by diffusion mechanism with matrix swelling, in which the release rate dependent on concentration of drug. The results indicated that the hydrolyzed hydrogels were potential for the application of oral controlled drug delivery system

Burapha University. Library

Address: CHONBURI

Email: buulibrary@buu.ac.th

Name: Thanida Trakulsujaritchok

Role: Principal advisor

Name: Piyaporn Na Nogkhai

Role: Co-advisor

Created: 2018

Modified: 2020-03-05

Issued: 2020-03-05

วิทยานิพนธ์/Thesis

application/pdf

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Polymer Science

Grantor: Burapha University

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