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Chaowalit Monton. Crosslinked hard gelatin capsule as a structural assembly of elementary and push-pull osmotic pump delivery system. Doctoral Degree(Pharmacy). Rangsit University Library. : Rangsit University, 2019.
Crosslinked hard gelatin capsule as a structural assembly of elementary and push-pull osmotic pump delivery system
การใช้แคปซูลเจลาตินแข็งแบบเชื่อมขวางเป็นโครงสร้างของระบบนำส่งยาชนิดออสโมติกปั๊มแบบพื้นฐานและแบบผลัก-ดึง Chaowalit Monton Rangsit University. Graduate School 2019
Name: Chaowalit Monton
MeSH:
Capsules
MeSH:
Gelatin capsules
Abstract:
The objective of this study was to characterize the crosslinked hard gelatin
capsules in order to use as a structural assembly of osmotic pump capsules for delivery
of different water solubility model drugs including diltiazem hydrochloride, propranolol
hydrochloride, ambroxol hydrochloride, and paracetamol. The hard gelatin capsules
(HGCs) were crosslinked by exposure to formaldehyde vapor for 6, 12, and 24 hours.
According to the results, the HGC shell crosslinked for 12 hours was selected for
preparation of elementary osmotic pump (EOP) and push-pull osmotic pump (PPOP)
due to its insoluble property, low formaldehyde residue, stability after storage, and
providing reproducible drug release profiles. Drug release from EOP capsules was
dependent of drug substance type and loading dose except diltiazem hydrochloride, a
very highly water soluble drug. Drug release from PPOP capsules was independent of
drug substance type, loading dose, and capsule size. But it was dependent of amount of
polyethylene oxide in a pull layer. The osmolality of release medium affected drug
release from PPOP capsules more than from EOP capsules. Drug release study using a
medium with digestive enzymes did not alter drug release compared to medium without
enzymes. EOP and PPOP capsules prepared using 12-month stored crosslinked HGCs
gave consistent release profiles compared to those prepared using initial crosslinked
HGCs. Almost all of the formulations gave drug release approaching Higuchis release
kinetic model. However, ambroxol hydrochloride could not deliver via these devices
because of its high dense drug particle. In summary, the developed EOP and PPOP
capsules were an alternative osmotic device that could be used for drug delivery systems
and were applicable for several drugs with different water solubilities.
Rangsit University Library
Address:
Pathumthani
Email:
rattanapornn@rsu.ac.th
Name: Poj Kulvanich
Role:
Advisor
Created:
2019
Modified:
2568-02-03
Issued:
2019-12-06
วิทยานิพนธ์/Thesis
application/pdf
eng
DegreeName: Doctor of Philosophy
Level: Doctoral Degree
Descipline: Pharmacy
Grantor: Rangsit University
©copyrights Rangsit University
RightsAccess:
ใช้เวลา
0.081875 วินาที
Chaowalit Monton
| Title | Contributor | Type |
|---|---|---|
| Crosslinked hard gelatin capsule as a structural assembly of elementary and push-pull osmotic pump delivery system
มหาวิทยาลัยรังสิต Chaowalit Monton | Poj Kulvanich | วิทยานิพนธ์/Thesis |
Poj Kulvanich