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Nareerat Thongtham. Encapsulation of cissus quadrangularis extracts in biopolymer scaffold to sustain release in bone tissue engineering. Master's Degree(Materials Science). Mae Fah Luang University. The Learning Resources and Education Media Center. : , 2018.
Encapsulation of cissus quadrangularis extracts in biopolymer scaffold to sustain release in bone tissue engineering
Name: Nareerat Thongtham
Address:
333 Moo1, Thasud, Muang, Chiang Rai 57100
Organization :
Mae Fah Luang University. School of Science. Materials Science
Email :
ask.library@mfu.ac.th
keyword:
Biopolymer
LCSH:
Tissue engineering
Classification :.LCCS: TP248.65.P62
LCSH:
Biomedical materials
LCSH:
Tissue Scaffolds
LCSH:
Biopolymers
Abstract:
The aim of this research was to fabricate the composite scaffolds (chitosan, collagen and hydroxyapatite; CS/Col/HA) with incorporation of Cissus quadrangularis extract (CQ) for use in bone tissue engineering application. CQ was extracted with different solvents (ethanol and hexane solvents) via soxhlet apparatus. First, ethanol CQ extract (ECQ) loaded in polycaprolactone (PCL) nanoparticles were prepared via double emulsion technique (water-oil-water). While, hexane CQ extract (HCQ) loaded in PCL nanoparticles were prepared via single emulsion (oil-water). The concentrations of PCL and polyvinyl alcohol (PVA) were optimized to fabricate the CQ loaded in nanoparticles with homogeneous size distributions and highest % encapsulation efficiency. The PCL nanoparticles encapsulated with ethanol extract CQ (ECQ-PCL nanoparticles), prepared with 20 mg/ml PCL and 0.5% w/v PVA exhibited the good homogeneous size distribution of 334.22±43.21 nm with the high encapsulation efficiency of 95.54±1.49%. The PCL nanoparticles encapsulated with hexane extract CQ (HCQ-PCL nanoparticles) prepared with 20 mg/ml PCL and 0.5% w/v PVA exhibited the size distribution of 488.23±94.82 nm with the high encapsulation efficiency of 83.36±0.93%. Then, the CQ-PCL nanoparticles incorporated in the CS/Col/HA scaffolds were prepared using freeze-drying technique. The scaffolds were studied for their ultrastructure, pore sizes, compressive modulus, water swelling, weight loss, and biocompatibility. The results showed that addition of ECQ-PCL and HCQ-PCL nanoparticles to CS/Col/HA scaffolds did not dramatically alter ultrastructure of the scaffolds and properties, compared to CS/Col/HA scaffolds alone. However, incorporation of CQ-PCL nanoparticles in the scaffolds improved the release profile of CQ by preventing the initial burst release and prolonging release rate of CQ. The CQ-PCL nanoparticles also supported attachment and proliferation of MC3T3-E1 osteoblast cells. Thus, these scaffolds may have a potential for use in bone tissue engineering applications.
Mae Fah Luang University. The Learning Resources and Education Media Center
Address:
Chiang Rai
Email:
library@mfu.ac.th
Name: Orawan Suwantong
Role:
Advisor
Email :
ask.library@mfu.ac.th
Name: Suwimon Boonrungsiman
Role:
Co-Advisor
Email :
ask.library@mfu.ac.th
Created:
2018
Issued:
2562
Modified:
2020-05-12
Issued:
2019-09-09
วิทยานิพนธ์/Thesis
application/pdf
CallNumber:
Thesis TP248.65.P62 N225e 2018
eng
DegreeName: Master of Science
Level: Master's Degree
Descipline: Materials Science
©copyrights Mae Fah Luang University
RightsAccess:
ใช้เวลา
0.037208 วินาที
Nareerat Thongtham
| Title | Contributor | Type |
|---|---|---|
| Encapsulation of cissus quadrangularis extracts in biopolymer scaffold to sustain release in bone tissue engineering
มหาวิทยาลัยแม่ฟ้าหลวง Nareerat Thongtham | Orawan Suwantong Suwimon Boonrungsiman | วิทยานิพนธ์/Thesis |
| Preparation of polycaprolactone nanoparticles loaded Cissus Quandrangularis extract by single emulsification technique for controlled release applications
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Nareerat Thongtham;Suwimon Boonrungsiman;Orawan Suwantong | บทความ/Article |
Orawan Suwantong
Suwimon Boonrungsiman
| Title | Creator | Type and Date Create |
|---|---|---|
| Encapsulation of cissus quadrangularis extracts in biopolymer scaffold to sustain release in bone tissue engineering
มหาวิทยาลัยแม่ฟ้าหลวง Orawan Suwantong;Suwimon Boonrungsiman | Nareerat Thongtham | วิทยานิพนธ์/Thesis |