Chemical constituents and biological activities of selected annonaceae plants: Desmos cochinchinensis, Friesodielsia desmoides, Goniothalamus tamirensis and Uvaria hamiltonii

Name: Pornphimon Meesakul

Address: 333 Moo1, Thasud, Muang, Chiang Rai 57100

Organization : Mae Fah Luang University. School of Science. Applied Chemistry

Email : ask.library@mfu.ac.th

keyword: Annonaceae plants

LCSH: Annonaceae

Classification :.LCCS: QK495.A6

LCSH: Biogeochemistry

Abstract: Phytochemical investigations of four Annonaceae plants; Desmos cochinchinensis, Friesodielsia desmoides, Goniothalamus tamirensis, and Uvaria hamiltonii led to isolation and identification of 70 compounds. The biological activities of some isolated compounds were evaluated. All compounds were characterized by spectroscopic methods by comparisons with literature data for known compounds. Four new flavonoids (2.1–2.4), a new benzyl benzoate derivative (2.5), five new oxepinones (2.6–2.10), and 14 known compounds (2.11–2.24) were isolated from the leaf and twig extracts of D. cochinchinensis. The structure of 2.1 was also confirmed by X-ray diffraction data. The absolute configurations of 2.3, 2.4, and 2.6–2.10 were determined from comparisons of their ECD spectra with those of relevant reported compounds. Compounds 2.1, 2.2, 2.6, 2.8, 2.10, 2.12–2.15, and 2.17 showed α-glucosidase inhibitory activity with IC50 values ranging from 0.2‒4.9 µM. The first phytochemical investigation of F. desmoides leaves and twigs led to the isolation and identification of three new hybrid flavan‒flavanones; friesodielsones A–C (3.1–3.3) together with 18 known compounds (3.4–3.21). Compounds 3.2 and 3.15 significantly inhibited NO production with IC50 values of 10.21±0.074 and 7.56±0.087 µM, respectively, whereas compounds 3.11 (IC50 = 28.14±0.024 µM) and 3.12 (IC50 = 37.21±0.017 µM) were moderate inhibitors. The phytochemical investigation of the leaf extracts of U. hamiltonii led to the isolation and identification of ten compounds including a new seco‒cyclohexene (4.1) together with nine known compounds (4.2–4.10). Compounds 4.2, 4.8, and 4.9 showed potent α-glucosidase inhibitory activity with IC50 values ranging from 2.6–7.1 µM. A phytochemical investigation of the twig and leaf extracts of G. tamirensis led to the isolation and identification of 15 compounds including three rare new styryllactones, goniotamirenones A‒C (5.1‒5.3) together with 12 known compounds (5.4–5.15). Compound 5.6 exhibited potent cytotoxicity against the colon cancer cell line (HCT116) with an IC50 value of 8.6 µM which was better than the standard control (doxorubicin, IC50 = 9.7 µM), while 5.9 showed good activity with an IC50 value of 22.1

Mae Fah Luang University. The Learning Resources and Education Media Center

Address: Chiang Rai

Email: library@mfu.ac.th

Name: Surat Laphookhieo

Role: Advisor

Email : ask.library@mfu.ac.th

Name: Wisanu Maneerat

Role: Co-Advisor

Email : ask.library@mfu.ac.th

Created: 2018

Issued: 2562

Modified: 2020-05-12

Issued: 2019-09-03

วิทยานิพนธ์/Thesis

application/pdf

CallNumber: Thesis QK495.A6 P836c 2018

eng

DegreeName: Dotor of Philosophy

Level: Doctoral Degree

Descipline: Applied Chemistry

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