A comparative study of the efficacy and satisfactory evaluation between 5% peppermint cream and 2% hydroquinone cream for the treatment of melasma in Thai people

Comparative study of the efficacy and satisfactory evaluation between 5% peppermint cream and 2% hydroquinone cream for the treatment of melasma in Thai people

Name: Thet, Nang War War

Address: 333 Moo1, Thasud, Muang, Chiang Rai 57100

Organization : Mae Fah Luang University. School of Anti-Aging and Regenerative Medicine. Dermatology

Email : ask.library@mfu.ac.th

keyword: Melasma

LCSH: Dermatology

Classification :.LCCS: WR100

LCSH: Cosmetic Techniques

LCSH: Skin Diseases

LCSH: Skin Pigmentation

LCSH: Skin Care

LCSH: Hydroquinones

Abstract: Background: Melasma is one of the most common cosmetic concerns with skin hyperpigmentation, brown symmetric macules on the face. Although several treatment modalities available, none is satisfactorily used in management of this condition. Mentha piperita is a natural herbal plants, which has the anti-tyrosinase activity (IC50 = 240 µg/ml), but there is no recent study in the treatment of melasma Aim: The aim of this study is to compare the efficacy and satisfactory evaluation between 5% peppermint cream and 2% hydroquinone cream for the treatment of melasma. Methods: Sixteen healthy women with bilateral melasma were enrolled in a split-face trial lasting 12 weeks. This is a double-blind, randomized split face, controlled clinical trial. Patients were asked to apply 5% peppermint cream and 2% hydroquinone cream, to the designated sides of the face twice daily and additional sunscreen when going out into sunlight. Skin pigmentation were measured using MASI (Melasma Area and Severity Index) and Mean Melanin Index using (Mexameter® MX 18) at each visit separately for each side at the base line and every month until one month after treatment course. Data were obtained from patients file and were analyzed statistically using SPSS software, paired samples t-test and repeated measured ANOVA test. Results: All sixteen volunteers completed the study. The mean MASI scores were significantly reduced in both treated sides (p value <0.001*) after 12 week. The mean Mexameter score were significantly reduced in both sides too with p value <0.001* for peppermint cream and p value <0.003 after 12th week. The mean percentage change of MASI score & Mexameter at follow-up 4th, 8th and 12th weeks between the 5% peppermint cream group not statistical difference with the 2% hydroquinone cream group. No adverse effects were noted throughout the study with both creams Conclusion: On the basis of these results, 5% peppermint cream can be used as a new, effective, safe, and promising therapeutic agent in melasma.

Mae Fah Luang University. The Learning Resources and Education Media Center

Address: Chiang Rai

Email: library@mfu.ac.th

Name: Rassapoom Sumaetheiwit

Role: Advisor

Email : ask.library@mfu.ac.th

Created: 2018

Issued: 2562

Modified: 2020-05-07

Issued: 2019-08-27

วิทยานิพนธ์/Thesis

application/pdf

CallNumber: Thesis WR100 T414c 2018

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Dermatology

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