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Aphichart Karnchanatat. Free radical scavenging properties and DNA damage protecting of peptide hydrolysate derived from edible mushroom Astraeus hygrometricus. (). King Mongkut's University of Technology North Bangkok. Central Library. : , 2017.
Free radical scavenging properties and DNA damage protecting of peptide hydrolysate derived from edible mushroom Astraeus hygrometricus
Name: Natpatsorn Tunyatarinun
Organization :
Chulalongkorn University. Faculty of science
Name: Onrapak Reamtong
Organization :
Mahidol University. Faculty of Tropical Medicine
Name: Papassara Sangtanoo
Organization :
Chulalongkorn University. Institute of Biotechnology and Genetic Engineering
Name: Tanatorn Saisavoey
Organization :
Chulalongkorn University. Institute of Biotechnology and Genetic Engineering
Name: Aphichart Karnchanatat
Organization :
Chulalongkorn University. Institute of Biotechnology and Genetic Engineering
Email :
Aphichart.K@chula.ac.th
keyword:
Free radical scavenging activities
LCSH:
DNA damage
LCSH:
Edible mushrooms
Abstract:
Mushrooms have been used as food and for therapeutic purpose for decades, and
various compounds derived from them have potential biological activities. The present study
aims to explore the free radical scavenging properties of peptides derived from the edible
mushroom Astraeus hygrometricus. In this work, peptides from A. hygrometricus protein
hydrolysates attainable with microbial proteases (Alcalase®, Flavourzyme® and Neutrase®)
were prepared and their antioxidant activities were determined. Peptide fractions derived from
A. hygrometricus hydrolyzed by 1% Alcalase®, showed the highest DPPH and ABTS radical
scavenging activities with IC50 values of 13.40±0.48 and 5.53±0.59 μg/mL, respectively.
Peptide fractions were obtained using molecular weight cut-offs of 10, 5, 3 and 0.65 kDa
membranes and their antioxidant properties were further analyzed. Among the fractions, MW
< 0.65 kDa (F5 fraction) exhibited high levels of free radical scavenging activities towards
DPPH and ABTS with IC50 values of 4.84±0.26 and 1.49±0.39 μg/mL, respectively. The F51
fraction from Superdex® 75 column presented the highest scavenging activities on DPPH and
ABTS radicals with IC50 values of 32.47±1.16 and 15.58±0.73 μg/mL, respectively.
Furthermore, the F51 fraction could protect hydroxyl radical-induced DNA damage as shown
in pKS, pUC19, and pBR322. Hence, F51 fraction could be used as natural antioxidant
feasible for drug development.
King Mongkut's University of Technology North Bangkok. Central Library
Address:
BANGKOK
Email:
library@kmutnb.ac.th
Created:
2017
Modified:
2562-07-24
Issued:
2019-07-24
บทความ/Article
application/pdf
BibliograpyCitation :
In Chemical Society of Thailand under the Patronage of Her Royal Hghness Princess Chulabhorn Mahidol and King Mongkut's University of Technology North Bangkok Faculty of Applied Science. Pure and Applied Chemistry International Conference (PACCON 2017) (pp.302-307). Bangkok : Chemical Society of Thailand under the Patronage of Her Royal Hghness Princess Chulabhorn Mahidol
eng
©copyrights King Mongkut's University of Technology North Bangkok
RightsAccess:
ใช้เวลา
0.035485 วินาที
Natpatsorn Tunyatarinun
| Title | Contributor | Type |
|---|---|---|
| Free radical scavenging properties and DNA damage protecting of peptide hydrolysate derived from edible mushroom Astraeus hygrometricus
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Natpatsorn Tunyatarinun;Onrapak Reamtong;Papassara Sangtanoo;Tanatorn Saisavoey;Aphichart Karnchanatat | บทความ/Article | |
| Free radical scavenging and antiproliferative activities of peptide from hygroscopic earthstar astraeus hygrometricus
จุฬาลงกรณ์มหาวิทยาลัย Natpatsorn Tunyatarinun | Aphichart Karnchanatat Onrapak Reamtong | วิทยานิพนธ์/Thesis |
Onrapak Reamtong
| Title | Contributor | Type |
|---|---|---|
| Screening of 3-hydroxy-3-methyl-glutaryl CoA reductase inhibitors from medicinal plants
จุฬาลงกรณ์มหาวิทยาลัย Onrapak Reamtong | Amorn Petsom Vasana Tolieng | วิทยานิพนธ์/Thesis |
| Free radical scavenging properties and DNA damage protecting of peptide hydrolysate derived from edible mushroom Astraeus hygrometricus
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Natpatsorn Tunyatarinun;Onrapak Reamtong;Papassara Sangtanoo;Tanatorn Saisavoey;Aphichart Karnchanatat | บทความ/Article |
Papassara Sangtanoo
| Title | Contributor | Type |
|---|---|---|
| Free radical scavenging properties and DNA damage protecting of peptide hydrolysate derived from edible mushroom Astraeus hygrometricus
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Natpatsorn Tunyatarinun;Onrapak Reamtong;Papassara Sangtanoo;Tanatorn Saisavoey;Aphichart Karnchanatat | บทความ/Article | |
| Optimization of preparing protein hydrolysate from Split Gill mushroom (Schizophyllum commune) by alcalase using response surface methodology (RSM)
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Aunchalee Wongaem;Papassara Sangtanoo;Aphichart Karnchanatat | บทความ/Article | |
| Optimization of shiitake mushroom (lentinula edodes) hydrolysate with angiotensin I converting enzyme inhibitory activity
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Supawee Paisansak;Papassara Sangtanoo;Aphichart Karnchanatat | บทความ/Article |
Tanatorn Saisavoey
| Title | Contributor | Type |
|---|---|---|
| Antimicrobial activity and antioxidant compositions of Kwao Krua extracts
มหาวิทยาลัยแม่ฟ้าหลวง Tanatorn Saisavoey | Ekachai Chukeatirote | วิทยานิพนธ์/Thesis |
| Free radical scavenging properties and DNA damage protecting of peptide hydrolysate derived from edible mushroom Astraeus hygrometricus
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Natpatsorn Tunyatarinun;Onrapak Reamtong;Papassara Sangtanoo;Tanatorn Saisavoey;Aphichart Karnchanatat | บทความ/Article |
Aphichart Karnchanatat