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Preecha Phuwapraisirisan. Antidiabetic activity of synthetic furofuran lignans containing multiphenolic groups. (). King Mongkut's University of Technology North Bangkok. Central Library. : , 2018.
Antidiabetic activity of synthetic furofuran lignans containing multiphenolic groups
Organization :
Chulalongkorn University. Faculty of Science
Organization :
Chulalongkorn University. Faculty of Science
Name: Wisuttaya Worawalai
Organization :
Chulalongkorn University. Faculty of Science
Name: Preecha Phuwapraisirisan
Organization :
Chulalongkorn University. Faculty of Science
Email :
preecha.p@chula.ac.th
keyword:
Furofuran lignans
LCSH:
Antidiabetics
Abstract:
Sesamolin (1) and sesamin (2) are major furofuran lignans found abundantly in
sesame (Sesamum indicum) seeds. Compounds 1 and 2 show several intriguing in vivo
biological activities, particularly antidiabetic activity. Current evidences indicated that they
are in fact the proactive precursor, which is subsequently converted by human intestinal
microbes to the true active metabolites. Noticeably, the enhanced bioactivity found in true
active metabolites is possibly caused by the presence of multiphenolic groups, especially
catechol moiety. To prove this postulate, a new series of furofuran lignans containing
multiphenolic groups were synthesized starting from 1 and 2. The synthesized lignans were
evaluated for their antidiabetic activity through a-glucosidase inhibition. Furofuran lignan
containing tetraphenolic groups (7) showed the most potent inhibition against maltase and
sucrase with IC50 values of 0.32 and 0.71 mM, respectively, while 1 and 2 showed no
inhibition. The observation suggested a-glucosidase inhibition depends on the numbers of
phenolic groups in lignan structure.
King Mongkut's University of Technology North Bangkok. Central Library
Address:
BANGKOK
Email:
library@kmutnb.ac.th
Created:
2018
Modified:
2019-07-22
Issued:
2019-07-12
บทความ/Article
application/pdf
BibliograpyCitation :
In Prince of Songkla University Faculty of Science. Pure and Applied Chemistry International Conference (PACCON 2018) (pp.OR27-OR31). Songkla : Prince of Songkla University
eng
©copyrights King Mongkut's University of Technology North Bangkok
RightsAccess:
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0.044712 วินาที
Titiruetai Doungwichitrkul
| Title | Contributor | Type |
|---|---|---|
| Antidiabetic activity of synthetic furofuran lignans containing multiphenolic groups
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Titiruetai Doungwichitrkul;Nantaporn Surachaitanawat;Wisuttaya Worawalai;Preecha Phuwapraisirisan | บทความ/Article | |
| Synthesis and antidiabetic activity of furofuran lignans containing multiphenolic groups
จุฬาลงกรณ์มหาวิทยาลัย Titiruetai Doungwichitrkul | Preecha Phuwapraisirisan | วิทยานิพนธ์/Thesis |
Nantaporn Surachaitanawat
| Title | Contributor | Type |
|---|---|---|
| Synthesis of new furofuran lignans through nucleophilic substitution of samin
จุฬาลงกรณ์มหาวิทยาลัย Nantaporn Surachaitanawat | Preecha Phuwapraisirisan Viwat Vchirawongkwin | วิทยานิพนธ์/Thesis |
| Antidiabetic activity of synthetic furofuran lignans containing multiphenolic groups
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Titiruetai Doungwichitrkul;Nantaporn Surachaitanawat;Wisuttaya Worawalai;Preecha Phuwapraisirisan | บทความ/Article |
Wisuttaya Worawalai
| Title | Contributor | Type |
|---|---|---|
| α-glucosidase inhibitors from aminocyclitol derivatives
จุฬาลงกรณ์มหาวิทยาลัย Wisuttaya Worawalai | Preecha Phuwapraisirisan Sumrit Wacharasindhu | วิทยานิพนธ์/Thesis |
| Antidiabetic activity of synthetic furofuran lignans containing multiphenolic groups
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Titiruetai Doungwichitrkul;Nantaporn Surachaitanawat;Wisuttaya Worawalai;Preecha Phuwapraisirisan | บทความ/Article | |
| α-GLUCOSIDASE INHIBITORS FROM N-SUBSTITUTED AMINOCYCLITOL DERIVATIVES AND TOTAL SYNTHESIS OF CJ-16,264
จุฬาลงกรณ์มหาวิทยาลัย Wisuttaya Worawalai | Preecha Phuwapraisirisan Sumrit Wacharasindhu | วิทยานิพนธ์/Thesis |
Preecha Phuwapraisirisan
| Title | Contributor | Type |
|---|---|---|
| Antidiabetic activity of synthetic furofuran lignans containing multiphenolic groups
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Titiruetai Doungwichitrkul;Nantaporn Surachaitanawat;Wisuttaya Worawalai;Preecha Phuwapraisirisan | บทความ/Article |