Detection of antinuclear antibodies and thepercentages of T regulatory and T helper 17 cells in HIV-infected individuals

การตรวจหาแอนตินิวเคลียร์ แอนติบอดี และค่าร้อยละของเซลล์ ทีเร็กกิวลาทอรี และทีเฮลเปอร์ 17 ในผู้ติดเชื้อเอชไอวี

Name: Kanyanee Promsawan

ThaSH: Immunoglobulins

Classification :.DDC: 616.0793

ThaSH: Antinuclear Antibodies (ANA)

ThaSH: HIV-positive persons

ThaSH: Medical technology

Abstract: In HIV infection, abnormalities were found in all lymphocyte majority due to chronic immune activation. Several B cell defects were found such as polyclonal B cell activation, poor antibody response to specific antigens and increase the production of autoantibodies. Many studies also reported the production of autoantibodies and autoimmune disease in HIV infected patients. Therefore, the aims of this study were to determine the prevalence of antinuclear antibody (ANA) production and investigate the percentages of Th17 and Treg in HIV infected patients, which the balance of these cells had an importance role in autoimmune disease. Seventy-six HIV infected patients who received ARV drugs with undetectable viral load and 100 healthy donors were enrolled in the study. A positive ANA test was detected in 25% and 22% from HIV infected patients and healthy blood donors, respectively. After ANA determination the subjects were divided into 4 groups; 1) HIV negative with ANA negative, 2) HIV negative with ANA positive, 3) HIV positive with ANA negative and 4) HIV positive with ANA positive to determine the percentage of Th17 and Treg. The average percentages of T helper 17 cells were 1.73, 1.65, 1.59 and 0.95 for group 1, 2, 3 and 4, respectively. The average percentages of Treg cells in those 4 groups were 3.89, 3.25, 3.35 and 3.94, respectively. The average of Th17 and Treg ratio was 0.70, 0.83, 0.49 and 0.30, respectively. There was no statistically significant difference among them at 95% confidence levels. Therefore, ANA and loss of Th17 /Treg balance might not commonly be found in HIV infected patients who responded to ARV drugs with undetectable viraemia. Since, there are many factors involved autoantibody production and immune cells homeostasis, further studies are required.

Chiang Mai University Library

Address: Chiang Mai

Email: cmulibref@cmu.ac.th

Name: Siriporn Chuchawankul

Role: Chairman

Name: Panthong Singboottra

Role: Member

Name: Phennapha Klangsinsirikul

Role: Member

Created: 2017

Modified: 2018-10-18

Issued: 2018-10-18

วิทยานิพนธ์/Thesis

application/pdf

CallNumber: Th 616.0793 K16D

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Medical Technology

Grantor: Chiang Mai University

ลำดับที่.	ชื่อแฟ้มข้อมูล	ขนาดแฟ้มข้อมูล	จำนวนเข้าถึง	วัน-เวลาเข้าถึงล่าสุด
1	mtech70517kps_full.pdf	3.03 MB

ใช้เวลา

0.033101 วินาที